nazwa: α–Synuclein (34–45) (human)
nr katalogowy: GA23996-1
cas: 2170181-52-7
producent: GLPBio
opakowanie: 1mg
cena: 1823,33 [Pln] (bez rabatu)
wyszukaj podobne produkty: 2170181-52-7
Formula: C59H101N15O18. Molecular weight: 1308,52. Solubility: Soluble in DMSO. Storage: Store at -20°C. Synonym: The Parkinson's disease-associated protein α-synuclein ( α-syn) is not only expressed in the cytoplasm of neurons, but also secreted in the extracellular space and internalized into glial cells through a lipid raft dependent process. Two distinct cholesterol-binding domains in α-synuclein were identified by Fantini and coworkers. The tilted peptide of α-synuclein (67-78) bound cholesterol with high affinity and was toxic for cultured astrocytes. A cholesterol recognition consensus motif with lower affinity for cholesterol and devoid of toxicity, is encased in the glycosphingolipid-binding domain (34-45) of α-synuclein. The authors propose that the association of α-synuclein with lipid rafts involves both the binding of α-synuclein (34-45) to glycosphingolipids, and the interaction of α-synuclein (67-78) with cholesterol..
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czas dostawy: Do potwierdzenia przez Chemat