nazwa: α–Synuclein (67–78) (human)

nr katalogowy: GA23999-1

cas: 2243206-99-5

producent: GLPBio

opakowanie: 1mg

cena: 1823,33 [Pln] (bez rabatu)

wyszukaj podobne produkty: 2243206-99-5

szczegóły:

Formula: C43H76N12O15. Molecular weight: 1001,14. Solubility: Soluble in DMSO. Storage: Store at -20°C. Synonym: The Parkinson's disease-associated protein α-synuclein ( α-syn) is not only expressed in the cytoplasm of neurons, but also secreted in the extracellular space and internalized into glial cells through a lipid raft dependent process. Two distinct cholesterol-binding domains in α-synuclein were identified by Fantini and coworkers. The tilted peptide of α-synuclein (67-78) bound cholesterol with high affinity and was toxic for cultured astrocytes. A cholesterol recognition consensus motif with lower affinity for cholesterol and devoid of toxicity, is encased in the glycosphingolipid-binding domain (34-45) of α-synuclein. The authors propose that the association of α-synuclein with lipid rafts involves both the binding of α-synuclein (34-45) to glycosphingolipids, and the interaction of α-synuclein (67-78) with cholesterol..

właściwości

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czas dostawy: Do potwierdzenia przez Chemat