nazwa: 6–FAM–AEEAc–Stichodactyla helianthus Neurotoxin (ShK)

nr katalogowy: GA20443-1

cas: 1927927-42-1

producent: GLPBio

opakowanie: 1mg

cena: 18298,69 [Pln] (bez rabatu)

wyszukaj podobne produkty: 1927927-42-1

szczegóły:

Formula: C196H295N55O57S7. Molecular weight: 4558,3. Solubility: Soluble in DMSO. Storage: Store at -20°C. Synonym: This ShK analog containing a fluorescein-6-carboxyl group attached through an {2-(2-aminoethoxy)ethoxy}acetic acid (AEEAc) linker to the ƒ-amino group of Arg¹, selectively blocked the voltage gated T-lymphocyte K? Kv1.3 channels implicated in the pathogenesis of experimental autoimmune encephalomyelitis. It potently blocked Kv1.3 channels at picomolar concentrations and exhibited >80 fold specificity for Kv1.3 over Kv1.1 and other Kv channels. In flow cytometry experiments, chronically activated rat and human T-lympocytes with >600 Kv1.3 channels/cell were readily distinguished from resting and acutely activated T-lymphocytes with lower Kv1.3 channel numbers. 6-FAM-AEEAc-Stichodactyla helianthus neurotoxin (ShK) may therefore be a useful tool to detect the presence of T-lymphocytes with high expression of Kv1.3 channels in normal and diseased tissues..

właściwości

czystość: No data

czas dostawy: Do potwierdzenia przez Chemat