nazwa: Amyloid β/A4 Protein Precursor₇₇₀ (740–770)
nr katalogowy: GA20719-1
cas: 1802086-24-3
producent: GLPBio
opakowanie: 1mg
cena: 2062,04 [Pln] (bez rabatu)
wyszukaj podobne produkty: 1802086-24-3
Formula: C162H243N45O52S2. Molecular weight: 3717,12. Solubility: Soluble in DMSO. Storage: Store at -20°C. Synonym: Amyloid β/A4 Protein Precursor??? (740-770) corresponds to a C-terminal amyloid precursor protein (APP) fragment known as C31. This fragment is intracellularly generated by proteolytic cleavage of APP by caspases-8 and -9. C31 had a proapoptotic and a cytotoxic effect on neuronal cells and was shown to be present in brains of Alzheimer's disease (AD) patients. In cultured cells caspase cleavage of APP was induced by amyloid β-protein and the subsequent generation of C31 contributed to the apoptotic cell death associated with amyloid β-protein. Amyloid precursor binding protein BP1 (APP-BP1) a cell cycle protein which is increased in AD brain was demonstrated to bind to the C31 region of APP and to mediate APP-induced apoptosis..
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czas dostawy: Do potwierdzenia przez Chemat