nazwa: CHMFL–PI3KD–317
nr katalogowy: GC65969-10
cas: 2244992-76-3
producent: GLPBio
opakowanie: 10mg
cena: 2689,22 [Pln] (bez rabatu)
wyszukaj podobne produkty: 2244992-76-3
Formula: C21H24ClN5O3S2. Molecular weight: 494,03. Storage: Store at -20°C. Synonym: CHMFL-PI3KD-317 is a highly potent, selective and orally active PI3Kδ inhibitor, with an IC50 of 6 nM, and exhibits over 10-1500 fold selectivity over other class I, II and III PIKK family isoforms, such as PI3K α (IC50, 62.6 nM), PI3Kβ (IC50, 284 nM), PI3K γ (IC50, 202.7 nM), PIK3C2A (IC50, >10000 nM), PIK3C2B (IC50, 882.3 nM), VPS34 (IC50, 1801.7 nM), PI4KIIIA (IC50, 574.1 nM) and PI4KIIIB (IC50, 300.2 nM). CHMFL-PI3KD-317 inhibits PI3Kδ-mediated Akt T308 phosphorylation in Raji cells, with an EC50 of 4.3 nM. CHMFL-PI3KD-317 has antiproliferative effects on cancer cells..
czystość: No data
czas dostawy: Do potwierdzenia przez Chemat