nazwa: LC–2
nr katalogowy: GC61766-25
cas: 2502156-03-6
producent: GLPBio
opakowanie: 25mg
cena: 13622,87 [Pln] (bez rabatu)
wyszukaj podobne produkty: 2502156-03-6
Formula: C59H71ClFN11O7S. Molecular weight: 1132,78. Solubility: DMSO: 50 mg/mL (44.14 mM, ultrasonic and warming and heat to 80°C). Storage: Store at -20°C. Synonym: LC-2 is a potent and first-in-class von Hippel-Lindau-based PROTAC capable of degrading endogenous KRAS G12C, with DC50s between 0.25 and 0.76 μM. LC-2 covalently binds KRAS G12C with a MRTX849 warhead and recruits the E3 ligase VHL, inducing rapid and sustained KRAS G12C degradation leading to suppression of MAPK signaling in both homozygous and heterozygous KRAS G12C cell lines..
czystość: No data
czas dostawy: Do potwierdzenia przez Chemat