nazwa: POB
nr katalogowy: GB40328-10
cas: 946135-39-3
producent: GLPBio
opakowanie: 10mg
cena: 1397,41 [Pln] (bez rabatu)
wyszukaj podobne produkty: 946135-39-3
Formula: C19H31N3O6. Molecular weight: 397,47. Synonym: POB (946135-39-3) is a transition state-based, cell permeable pro-drug inhibitor of ODC, a key enzyme involved in polyamine synthesis and a potential cancer drug target. Intracellularly, POB is phosphorylated by pyridoxal kinase and the methyl ester hydrolyzed. This active inhibitor most likely binds apo-ODC resulting in greatly reduced ODC activity and inhibition of cellular proliferation. POB was able to inhibit proliferation in a wide variety of tumor cell lines: LN229 (IC50 = 50 μM), Jurkat, COS7, SW2 and both high and low-grade glioblastoma multiforme. More potent than DFMO..
czystość: No data
czas dostawy: Do potwierdzenia przez Chemat