nazwa: SGI 1027 dihydrochloride – S 1027 dihydrochloride
nr katalogowy: GB40366-10
cas: 2108487-01-8
producent: GLPBio
opakowanie: 10mg
cena: 2113,52 [Pln] (bez rabatu)
wyszukaj podobne produkty: 2108487-01-8
Formula: C27H25Cl2N7O. Molecular weight: 534,44. Synonym: SGI 1027 inhibits DNMT activity (IC50 values 35 µM and 10 µM for DNMT1 and DNMT3A2/3L, respectively) in colon cancer cell lines, and was shown to degrade the enzymes. Prolonged treatment of RKO cells with SGI 1027 led to demethylation and reexpression of the silenced tumor suppressor genes (TSGs) P16, MLH1, and TIMP3 and did not exhibit significant toxicity in a rat hepatoma (H4IIE) cell line. SGI 1027 shows moderate affinity (IC 50 value 65 µM) for G9a-like protein (GLP), another AdoMet-dependent enzyme, as well..
czystość: No data
czas dostawy: Do potwierdzenia przez Chemat