nazwa: Smac–N7 Peptide
nr katalogowy: GA23505-5
cas: 401913-57-3
producent: GLPBio
opakowanie: 5mg
cena: 3826,58 [Pln] (bez rabatu)
wyszukaj podobne produkty: 401913-57-3
Formula: C33H59N9O9. Molecular weight: 725,89. Solubility: Soluble in DMSO. Storage: Store at -20°C. Synonym: Smac-N7 Peptide corresponds to the N-terminal seven residues of Smac (second mitochondria-derived activator of caspase) also known as DIABLO. Smac/DIABLO is a mitochondrial proapoptotic protein that activates caspases in the cytochrome c/Apaf-1/caspase-9 pathway by neutralizing inhibitor of apoptosis protein (IAP).Smac-N7 peptide promoted procaspase-3 activation in vitro at around 10 µM and inhibited binding of caspase-9-p12 to the BIR3 (baculoviral IAP repeat 3) domain of XIAP (X-linked IAP).The finding that Smac/DIABLO agonists could enhance the apoptosis-inducing potential of irradiation and chemotherapeutic drugs might lead to promising new candidates for cancer treatment..
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czas dostawy: Do potwierdzenia przez Chemat