nazwa: XIB4035
nr katalogowy: GB40418-5
cas: 10023-54-8
producent: GLPBio
opakowanie: 5mg
cena: 1256,99 [Pln] (bez rabatu)
wyszukaj podobne produkty: 10023-54-8
Formula: C26H31Cl2N3?3(H3PO4). Molecular weight: 750,45. Synonym: XIB4035 (10023-54-8) is a novel small molecule thought to be an agonist at the glial cell line-derived neurotrophic factor (GDNF) family receptor GFR α-1. It inhibits radiolabeled GDNF binding in Neuro-2A cells in a concentration dependent manner IC50 = 10.4 μM. Like GDNF, XIB4035 induced Ret autophosphorylation and promoted neurite outgrowth in Neuro-2A cells. Recent studies indicate that it enhances GFR α family receptor signaling in conjunction with ligand stimulation. Effective treatment for small-fiber neuropathy in mouse models of the disease. GDNF agonists may be a new class of Parkinson's disease therapeutics..
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czas dostawy: Do potwierdzenia przez Chemat