ABT–737
cas: 852808-04-9 — see every product listed under this CAS number, including other names
ABT–737 (CAS 852808-04-9) is a chemical reagent available from Chemat. Available pack sizes: 10mg, 100mg, 200mg, 5mg, 10mM (in 1ml dmso), 50mg. Offered by: GLPBio.
| brand | GLPBio |
|---|---|
| catalog number | GC17234-10 |
| cas | 852808-04-9 |
| size | 10mg |
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Available pack sizes
| brand | size | price | |
|---|---|---|---|
| GLPBio | 10mg | 709.37 Pln | |
| GLPBio | 100mg | 2150.97 Pln | |
| GLPBio | 200mg | 3297.69 Pln | |
| GLPBio | 5mg | 662.57 Pln | |
| GLPBio | 10mM (in 1ml dmso) | 685.97 Pln | |
| GLPBio | 50mg | 1397.41 Pln |
properties
| purity | No data |
|---|---|
| delivery time | To be confirmed by Chemat |
ABT-737 is a biphenyl that is 4-chloro-1,1'-biphenyl substituted by a (4-{4-[(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrobenzene-1-sulfonyl)carbamoyl]phenyl}piperazin-1-yl)methyl group at position 2'. It is a BH3-mimetic drug which targets the anti-apoptotic B-cell lymphoma-2 (BCL-2) family proteins, including BCL-2, BCL-xL, and BCL-w, and induces apoptosis in cancer cells. It has a role as a B-cell lymphoma 2 inhibitor, an antineoplastic agent, an anti-allergic agent, an anti-inflammatory agent and an apoptosis inducer. It is a member of biphenyls, an aromatic amine, an aryl sulfide, a C-nitro compound, a N-arylpiperazine, a secondary amino compound, a tertiary amino compound, a member of monochlorobenzenes and a N-sulfonylcarboxamide.
Source: ChEBI
| Molecular formula | C42H45ClN6O5S2 |
|---|---|
| Molecular weight | 813.4 g/mol |
| IUPAC name | 4-[4-[[2-(4-chlorophenyl)phenyl]methyl]piperazin-1-yl]-N-[4-[[(2R)-4-(dimethylamino)-1-phenylsulfanylbutan-2-yl]amino]-3-nitrophenyl]sulfonylbenzamide |
| InChIKey | HPLNQCPCUACXLM-PGUFJCEWSA-N |
| SMILES | CN(C)CC[C@H](CSC1=CC=CC=C1)NC2=C(C=C(C=C2)S(=O)(=O)NC(=O)C3=CC=C(C=C3)N4CCN(CC4)CC5=CC=CC=C5C6=CC=C(C=C6)Cl)[N+](=O)[O-] |
Computed by PubChem (NCBI)