AZD8835
cas: 1620576-64-8 — see every product listed under this CAS number, including other names
AZD8835 (CAS 1620576-64-8) is a chemical reagent available from Chemat. Available pack sizes: 1mg, 10mg, 25mg, 5mg. Offered by: GLPBio.
| brand | GLPBio |
|---|---|
| catalog number | GC11248-1 |
| cas | 1620576-64-8 |
| size | 1mg |
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Available pack sizes
| brand | size | price | |
|---|---|---|---|
| GLPBio | 1mg | 648.53 Pln | |
| GLPBio | 10mg | 1776.53 Pln | |
| GLPBio | 25mg | 3250.88 Pln | |
| GLPBio | 5mg | 1154.02 Pln |
properties
| purity | No data |
|---|---|
| delivery time | To be confirmed by Chemat |
AZD-8835 is a member of the class of triazoles that is 1H-1,2,4-triazole substituted by ethyl, 1-(3-hydroxypropanoyl)piperidin-4-yl, and 5-amino-6-(5-tert-butyl-1,3,4-oxadiazol-2-yl)pyrazin-2-yl groups at positions 1, 3, and 5, respectively. It is a potent inhibitor of PI3Kalpha and PI3Kdelta (IC50 = of 6.2 and 5.7 nM, respectively) which was in a phase 1 clinical trial for the treatment of advanced solid tumours (trial now discontinued). It has a role as an antineoplastic agent, a bone density conservation agent, an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor and an apoptosis inducer. It is a primary alcohol, a member of triazoles, a member of pyrazines, a member of 1,3,4-oxadiazoles and a N-acylpiperidine.
Source: ChEBI
| Molecular formula | C22H31N9O3 |
|---|---|
| Molecular weight | 469.5 g/mol |
| IUPAC name | 1-[4-[5-[5-amino-6-(5-tert-butyl-1,3,4-oxadiazol-2-yl)pyrazin-2-yl]-1-ethyl-1,2,4-triazol-3-yl]piperidin-1-yl]-3-hydroxypropan-1-one |
| InChIKey | ZGRDYKFVDCFJCZ-UHFFFAOYSA-N |
| SMILES | CCN1C(=NC(=N1)C2CCN(CC2)C(=O)CCO)C3=CN=C(C(=N3)C4=NN=C(O4)C(C)(C)C)N |
Computed by PubChem (NCBI)