cas: 1138549-36-6 — see every product listed under this CAS number, including other names
CX-5461 (Standard) (CAS 1138549-36-6) is a chemical reagent available from Chemat. Available pack sizes: 50 mg, 10 mg, 25 mg, 100 mg, 5 mg. Offered by: MedChemExpress.
| brand | MedChemExpress |
|---|---|
| catalog number | HY-13323R-50 mg |
| cas | 1138549-36-6 |
| size | 50 mg |
| availability | Get quote |
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| brand | size | price | |
|---|---|---|---|
| MedChemExpress | 50 mg | 6115.40 Pln | |
| MedChemExpress | 10 mg | 2339.83 Pln | |
| MedChemExpress | 25 mg | 4118.48 Pln | |
| MedChemExpress | 100 mg | 9115.43 Pln | |
| MedChemExpress | 5 mg | 1596.79 Pln |
| delivery time | over 3 weeks |
|---|---|
| purity | no data |
CX-5461 is an organic heterotetracyclic compound that is 5-oxo-5H-[1,3]benzothiazolo[3,2-a][1,8]naphthyridine-6-carboxylic acid substituted by a 4-methyl-1,4-diazepan-1-yl group at position 2 and in which the carboxy group at position 6 is substituted by a [(5-methylpyrazin-2-yl)methyl]nitrilo group. An inhibitor of ribosomal RNA (rRNA) synthesis which specifically inhibits RNA polymerase I-driven transcription of rRNA in several cancer cell lines. It is currently in phase I/II clinical trials for advanced hematologic malignancies and triple-negative breast cancer with BRCA1/2 mutation. It has a role as an antineoplastic agent, an EC 2.7.7.6 (RNA polymerase) inhibitor and an apoptosis inducer. It is a secondary carboxamide, an organic heterotetracyclic compound, a member of pyrazines, a diazepine and a naphthyridine derivative.
Source: ChEBI
| Molecular formula | C27H27N7O2S |
|---|---|
| Molecular weight | 513.6 g/mol |
| IUPAC name | 2-(4-methyl-1,4-diazepan-1-yl)-N-[(5-methylpyrazin-2-yl)methyl]-5-oxo-[1,3]benzothiazolo[3,2-a][1,8]naphthyridine-6-carboxamide |
| InChIKey | XGPBJCHFROADCK-UHFFFAOYSA-N |
| SMILES | CC1=CN=C(C=N1)CNC(=O)C2=C3N(C4=CC=CC=C4S3)C5=C(C2=O)C=CC(=N5)N6CCCN(CC6)C |
Computed by PubChem (NCBI)