Celastrol, >95% (HPLC)
cas: 34157-83-0 — see every product listed under this CAS number, including other names
Celastrol, >95% (HPLC) (CAS 34157-83-0) is a chemical reagent available from Chemat. Available pack sizes: 10mg, 5mg. Offered by: TRC.
| brand | TRC |
|---|---|
| catalog number | TRC-C249500-10MG |
| cas | 34157-83-0 |
| size | 10mg |
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Available pack sizes
| brand | size | price | |
|---|---|---|---|
| TRC | 10mg | price on request | |
| TRC | 5mg | price on request |
properties
| purity | >95% (HPLC) |
|---|---|
| delivery time | To be confirmed by Chemat |
Celastrol is a pentacyclic triterpenoid that is 24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid bearing an oxo substituent at position 2, a hydroxy substituent at position 3 and two methyl groups at positions 9 and 13. An antioxidant and anti-inflammatory agent. Potently inhibits lipid peroxidation in mitochondria and inhibits TNF-alpha-induced NFB activation. Also shown to inhibit topoisomerase II activity in vitro (IC50 = 7.41 M). It has a role as an antioxidant, a metabolite, an anti-inflammatory drug, an antineoplastic agent, an EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor and a Hsp90 inhibitor. It is a monocarboxylic acid and a pentacyclic triterpenoid.
Source: ChEBI
| Molecular formula | C29H38O4 |
|---|---|
| Molecular weight | 450.6 g/mol |
| IUPAC name | (2R,4aS,6aR,6aS,14aS,14bR)-10-hydroxy-2,4a,6a,6a,9,14a-hexamethyl-11-oxo-1,3,4,5,6,13,14,14b-octahydropicene-2-carboxylic acid |
| InChIKey | KQJSQWZMSAGSHN-JJWQIEBTSA-N |
| SMILES | CC1=C(C(=O)C=C2C1=CC=C3[C@]2(CC[C@@]4([C@@]3(CC[C@@]5([C@H]4C[C@](CC5)(C)C(=O)O)C)C)C)C)O |
Computed by PubChem (NCBI)