cas: 670220-88-9 — see every product listed under this CAS number, including other names
Crenolanib (Standard), 98.12% (CAS 670220-88-9) is a chemical reagent available from Chemat. Available pack sizes: 25 mg, 5 mg, 100 mg, 1 mg, 10 mg, 50 mg. Offered by: MedChemExpress.
| brand | MedChemExpress |
|---|---|
| catalog number | HY-13223R-25 mg |
| cas | 670220-88-9 |
| size | 25 mg |
| availability | Get quote |
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| brand | size | price | |
|---|---|---|---|
| MedChemExpress | 25 mg | 3356.87 Pln | |
| MedChemExpress | 5 mg | 1318.15 Pln | |
| MedChemExpress | 100 mg | 6909.53 Pln | |
| MedChemExpress | 1 mg | 695.86 Pln | |
| MedChemExpress | 10 mg | 1917.23 Pln | |
| MedChemExpress | 50 mg | 4963.69 Pln |
| delivery time | over 3 weeks |
|---|---|
| purity | 98.12% |
Crenolanib is a member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a 8-(4-aminopiperidin-1-yl)quinolin-2-yl group at position 1 and by a (3-methyloxetan-3-yl)methoxy group at position 5. It is an inhibitor of type III tyrosine kinases, PDGFRalpha/beta and FLT3 (IC50 of 11, 3.2, and 4 nM). Currently under clinical development for the treatment of acute myeloid leukemia. It has a role as an antineoplastic agent, an angiogenesis inhibitor, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor and an apoptosis inducer. It is a member of benzimidazoles, a member of quinolines, an aromatic ether, a member of oxetanes, an aminopiperidine and a tertiary amino compound.
Source: ChEBI
| Molecular formula | C26H29N5O2 |
|---|---|
| Molecular weight | 443.5 g/mol |
| IUPAC name | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy]benzimidazol-1-yl]quinolin-8-yl]piperidin-4-amine |
| InChIKey | DYNHJHQFHQTFTP-UHFFFAOYSA-N |
| SMILES | CC1(COC1)COC2=CC3=C(C=C2)N(C=N3)C4=NC5=C(C=CC=C5N6CCC(CC6)N)C=C4 |
Computed by PubChem (NCBI)