Products 110417-88-4

CAS 110417-88-4 appears in our catalog under these names: Dolastatin 10/ 99.55% (existing batch purity), Dolastatin 10, Dolastatin 10 98%, Dolastatin 10, Dolastatin 10, 98.34%. Offered by: TargetMol, GLPBio, Ambeed, Chemat, MedChemExpress. Available pack sizes: 1mg, 2mg, 5mg, 10mg, 25mg, 50mg, 100 mg, 50 mg.

Dolastatin 10/ 99.55% (existing batch purity)
TargetMol
  • size: 1mg, 2mg, 5mg, 10mg
  • Variants: 6
from 1541.60
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Dolastatin 10
GLPBio
  • size: 1mg, 5mg
  • Variants: 2
from 1678.24
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Dolastatin 10 98%
Ambeed
  • size: 1mg, 5mg, 10mg, 25mg
  • Variants: 5
from 331.44
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Dolastatin 10
Chemat
  • size: 1mg, 5mg, 10mg, 25mg
  • Variants: 4
from 357.20
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Dolastatin 10, 98.34%
MedChemExpress
  • size: 100 mg, 50 mg, 25 mg, 1 mg
  • Variants: 6
from 528.67
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Dolastatin 10, ≥98%
Fluorochem
  • size: 1mg, 5mg, 10mg, 25mg
  • Variants: 4
from 586.27
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Structural formula: {0} (CAS {1})

Dolastatin 10 is a tetrapeptide that is isolated from the sea hare Dolabella auricularia. It is a potent anticancer agent which inhibits tubulin polymerization. It has a role as an antineoplastic agent, a microtubule-destabilising agent, an apoptosis inducer, an animal metabolite and a marine metabolite. It is a member of 1,3-thiazoles and a tetrapeptide. It is functionally related to a L-valine.

Source: ChEBI

Identity
Molecular formulaC42H68N6O6S
Molecular weight785.1 g/mol
IUPAC name(2S)-2-[[(2S)-2-(dimethylamino)-3-methylbutanoyl]amino]-N-[(3R,4S,5S)-3-methoxy-1-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(1,3-thiazol-2-yl)ethyl]amino]propyl]pyrrolidin-1-yl]-5-methyl-1-oxoheptan-4-yl]-N,3-dimethylbutanamide
InChIKeyOFDNQWIFNXBECV-VFSYNPLYSA-N
SMILESCC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@@H](C)C(=O)N[C@@H](CC2=CC=CC=C2)C3=NC=CS3)OC)OC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)N(C)C

Computed by PubChem (NCBI)

Synonyms: Dolastatin 10, Dolastatin-10, Deo-Dola 10, Dolostatin 10, Dolastatin10, Dolastin, orb1296722, Dolastatin 10; DLS 10; NSC 376128