Flumatinib (HHGV678)
cas: 895519-90-1 — see every product listed under this CAS number, including other names
Flumatinib (HHGV678) (CAS 895519-90-1) is a chemical reagent available from Chemat. Available pack sizes: 10mg, 10mM (in 1ml dmso), 5mg, 50mg. Offered by: GLPBio.
| brand | GLPBio |
|---|---|
| catalog number | GC32867-10 |
| cas | 895519-90-1 |
| size | 10mg |
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Available pack sizes
| brand | size | price | |
|---|---|---|---|
| GLPBio | 10mg | 798.30 Pln | |
| GLPBio | 10mM (in 1ml dmso) | 784.26 Pln | |
| GLPBio | 5mg | 718.73 Pln | |
| GLPBio | 50mg | 1233.59 Pln |
properties
| purity | No data |
|---|---|
| delivery time | To be confirmed by Chemat |
Flumatinib is a secondary carboxamide resulting from the formal condensation of the carboxy group of 4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)benzoic acid with the amino group of 2-methyl-N3-[4-(pyridin-3-yl)pyrimidin-2-yl]pyridine-3,5-diamine. It is an inhibitor of the non-receptor tyrosine kinase Bcr-Abl (IC50 = 1.2 nM) and has been approved in China for the treatment of chronic myeloid leukaemia. It has a role as an antineoplastic agent, an apoptosis inducer and an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor. It is a secondary carboxamide, a member of benzamides, an aminopyridine, an aminopyrimidine, a N-methylpiperazine, a secondary amino compound and a member of (trifluoromethyl)benzenes.
Source: ChEBI
| Molecular formula | C29H29F3N8O |
|---|---|
| Molecular weight | 562.6 g/mol |
| IUPAC name | 4-[(4-methylpiperazin-1-yl)methyl]-N-[6-methyl-5-[(4-pyridin-3-ylpyrimidin-2-yl)amino]-3-pyridinyl]-3-(trifluoromethyl)benzamide |
| InChIKey | BJCJYEYYYGBROF-UHFFFAOYSA-N |
| SMILES | CC1=C(C=C(C=N1)NC(=O)C2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)NC4=NC=CC(=N4)C5=CN=CC=C5 |
Computed by PubChem (NCBI)