GSK343

cas: 1346704-33-3 — see every product listed under this CAS number, including other names

GSK343 (CAS 1346704-33-3) is a chemical reagent available from Chemat. Available pack sizes: 10mg, 25mg, 5mg, 10mM (in 1ml dmso), 100mg, 50mg. Offered by: GLPBio, Biosynth.

brandGLPBio
catalog numberGC17534-10
cas1346704-33-3
size10mg
Need more information?

Ask us about this product — we're happy to help.

Available pack sizes

brand size price
GLPBio 10mg 746.82 Pln
GLPBio 25mg 1107.21 Pln
GLPBio 5mg 611.08 Pln
GLPBio 10mM (in 1ml dmso) 676.61 Pln
Biosynth 5mg price on request
Biosynth 10mg price on request
Biosynth 25mg price on request
Biosynth 100mg price on request
Biosynth 50mg price on request

properties

purityNo data
delivery timeTo be confirmed by Chemat
Structural formula: {0} (CAS {1})

GSK343 is a member of the class of indazoles that is 1-isopropyl-1H-indazole-4-carboxamide in which the nitrogen of the carboxamide group is substituted by a (6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl group and in which the indazole ring is substituted at position 6 by a 2-(4-methylpiperazin-1-yl)pyridin-4-yl group. A highly potent and selective EZH2 inhibitor (IC50 = 4 nM). It has a role as an EC 2.1.1.43 (enhancer of zeste homolog 2) inhibitor, an antineoplastic agent and an apoptosis inducer. It is a secondary carboxamide, a pyridone, an aminopyridine, a member of indazoles, a N-alkylpiperazine and a N-arylpiperazine.

Source: ChEBI

Identity
Molecular formulaC31H39N7O2
Molecular weight541.7 g/mol
IUPAC nameN-[(6-methyl-2-oxo-4-propyl-1H-pyridin-3-yl)methyl]-6-[2-(4-methylpiperazin-1-yl)-4-pyridinyl]-1-propan-2-ylindazole-4-carboxamide
InChIKeyULNXAWLQFZMIHX-UHFFFAOYSA-N
SMILESCCCC1=C(C(=O)NC(=C1)C)CNC(=O)C2=C3C=NN(C3=CC(=C2)C4=CC(=NC=C4)N5CCN(CC5)C)C(C)C

Computed by PubChem (NCBI)

Synonyms: compound 6 [PMID 24900432], orb1226482, orb1301110
Isomers (same molecular formula)
N-[(4,6-dimethyl-2-oxo-1H-pyridin-3-yl)methyl]-1-propan-2-yl-6-[6-(4-propan-2-ylpiperazin-1-yl)-3-pyridinyl]indazole-4-carboxamide C31H39N7O2

Also listed as

GSK343/ 99.9% TargetMol CAS 1346704-33-3
GSK343, 99.46% MedChemExpress CAS 1346704-33-3
GSK343 (Standard) MedChemExpress CAS 1346704-33-3
1-Isopropyl-N-((6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl)-6-(2-(4-methylpiperazin-1-yl)pyridin-4-yl)-1H-indazole-4-carboxamide, 99% (HPLC) BLDpharm CAS 1346704-33-3
GSK343 >= 98 % HPLC Sigma-Aldrich CAS 1346704-33-3
GSK343, 99% (HPLC) Chemat CAS 1346704-33-3