Glasdegib (Standard)
cas: 1095173-27-5 — see every product listed under this CAS number, including other names
Glasdegib (Standard) (CAS 1095173-27-5) is a chemical reagent available from Chemat. Available pack sizes: 5 mg, 10 mg, 100 mg, 25 mg, 50 mg. Offered by: MedChemExpress.
| brand | MedChemExpress |
|---|---|
| catalog number | HY-16391R-5 mg |
| cas | 1095173-27-5 |
| size | 5 mg |
| availability | Get quote |
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Available pack sizes
| brand | size | price | |
|---|---|---|---|
| MedChemExpress | 5 mg | 1318.15 Pln | |
| MedChemExpress | 10 mg | 2065.84 Pln | |
| MedChemExpress | 100 mg | 9473.02 Pln | |
| MedChemExpress | 25 mg | 4016.32 Pln | |
| MedChemExpress | 50 mg | 6356.89 Pln |
properties
| delivery time | over 3 weeks |
|---|---|
| purity | no data |
Glasdegib is a member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a (2R,4S)-4-{[(4-cyanophenyl)carbamoyl]amino}-1-methylpiperidin-2-yl group at position 2. It is a hedgehog signalling pathway inhibitor that acts by binding to Smoothened (SMO) receptors and blocking signal transduction (IC50 = 5 nM). It is used in combination with low-dose cytarabine, for the treatment of newly-diagnosed acute myeloid leukemia (AML) in adult patients (aged 75 years), or who have medical conditions that prevent the use of standard chemotherapy. It has a role as a Hedgehog signaling pathway inhibitor, an antineoplastic agent and a SMO receptor antagonist. It is a member of phenylureas, a nitrile, a member of benzimidazoles and a member of piperidines.
Source: ChEBI
| Molecular formula | C21H22N6O |
|---|---|
| Molecular weight | 374.4 g/mol |
| IUPAC name | 1-[(2R,4R)-2-(1H-benzimidazol-2-yl)-1-methylpiperidin-4-yl]-3-(4-cyanophenyl)urea |
| InChIKey | SFNSLLSYNZWZQG-VQIMIIECSA-N |
| SMILES | CN1CC[C@H](C[C@@H]1C2=NC3=CC=CC=C3N2)NC(=O)NC4=CC=C(C=C4)C#N |
Computed by PubChem (NCBI)