Histrelin

cas: 76712-82-8 — see every product listed under this CAS number, including other names

Histrelin (CAS 76712-82-8) is a chemical reagent available from Chemat. Available pack sizes: on request, Get quote. Offered by: Chemat Brand, MedChemExpress.

brandChemat Brand
catalog numberULH047001
cas76712-82-8
sizeon request
availability Do potwierdzenia przez Chemat|To be confirmed by Chemat
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purityNo data
categoryChemicals
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Structural formula: {0} (CAS {1})

Histrelin is an oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, 1-benzyl-D-histidyl, leucyl, arginyl, and N-ethylprolinamide residues joined in sequence. It is a synthetic nonapeptide analogue of gonadotropin-releasing hormone, and is used as a subcutaneous hydrogel implant (particularly as the diacetate salt) for the treatment of prostate cancer and for the suppression of gonadal sex hormone production in children with central precocious puberty. It has a role as an antineoplastic agent and a gonadotropin releasing hormone agonist.

Source: ChEBI

Identity
Molecular formulaC66H86N18O12
Molecular weight1323.5 g/mol
IUPAC name(2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2R)-3-(1-benzylimidazol-4-yl)-1-[[(2S)-1-[[(2S)-5-(diaminomethylideneamino)-1-[(2S)-2-(ethylcarbamoyl)pyrrolidin-1-yl]-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]-5-oxopyrrolidine-2-carboxamide
InChIKeyHHXHVIJIIXKSOE-QILQGKCVSA-N
SMILESCCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC2=CN(C=N2)CC3=CC=CC=C3)NC(=O)[C@H](CC4=CC=C(C=C4)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC5=CNC6=CC=CC=C65)NC(=O)[C@H](CC7=CN=CN7)NC(=O)[C@@H]8CCC(=O)N8

Computed by PubChem (NCBI)

Synonyms: histrelin, Histrelina, Histreline, Histrelinum, ((ImBl)-D-His(sub 6),Pro(sub 9)-NEt)LHRH, IBHPE-LHRH, imbzl-His(6), Pro(9)-NET-GNRH, ((im bzl)-D-His(6), Pro(9)-NEt)LHRH, GnRH, His(imBzl)(6)-N-Et-ProNH2(9)-, LHRH, His(imBzl)(6)-N-Et-ProNH2(9)-

Also listed as

Histrelin Acetate Biosynth CAS 76712-82-8