MK-8353 (SCH900353)

cas: 1184173-73-6 — see every product listed under this CAS number, including other names

MK-8353 (SCH900353) (CAS 1184173-73-6) is a chemical reagent available from Chemat. Available pack sizes: 25mg, 10mg, 50mg. Offered by: Biosynth.

brandBiosynth
catalog numberJXB17373-25mg
cas1184173-73-6
size25mg
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Available pack sizes

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Biosynth 10mg price on request
Biosynth 50mg price on request

properties

categoryLife Sciences
purityNo data
delivery time3-4 Weeks

MK-8353 is a member of the class of indazoles that is 1H-indazole substituted by a 6-(propan-2-yloxy)pyridin-3-yl group at position 3 and by a {[(3S)-3-(methylsulfanyl)-1-(2-{4-[4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl]-3,6-dihydropyridin-1(2H)-yl}-2-oxoethyl)pyrrolidin-3-yl]carbonyl}amino group at position 5. It is a potent and selective inhibitor of ERK1 and ERK2 in vitro (IC50 values of 23.0 nM and 8.8 nM, respectively). The drug is being developed by Merck Sharp & Dohme and is currently in clinical development for the treatment of advanced/metastatic solid tumors. It has a role as an antineoplastic agent, an apoptosis inducer and an EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor. It is a secondary carboxamide, a tertiary carboxamide, a member of pyridines, an aromatic ether, a member of triazoles, a member of indazoles, a pyrrolidinecarboxamide, a N-alkylpyrrolidine, a dihydropyridine and a methyl sulfide.

Source: ChEBI

Identity
Molecular formulaC37H41N9O3S
Molecular weight691.8 g/mol
IUPAC name(3S)-3-methylsulfanyl-1-[2-[4-[4-(1-methyl-1,2,4-triazol-3-yl)phenyl]-3,6-dihydro-2H-pyridin-1-yl]-2-oxoethyl]-N-[3-(6-propan-2-yloxy-3-pyridinyl)-1H-indazol-5-yl]pyrrolidine-3-carboxamide
InChIKeyKPQQGHGDBBJGFA-QNGWXLTQSA-N
SMILESCC(C)OC1=NC=C(C=C1)C2=NNC3=C2C=C(C=C3)NC(=O)[C@@]4(CCN(C4)CC(=O)N5CCC(=CC5)C6=CC=C(C=C6)C7=NN(C=N7)C)SC

Computed by PubChem (NCBI)

Synonyms: ERK Inhibitor MK-8353, orb1309415
Related forms of this compound
(3R)-3-methylsulfanyl-1-[2-[4-[4-(1-methyl-1,2,4-triazol-3-yl)phenyl]-3,6-dihydro-2H-pyridin-1-yl]-2-oxoethyl]-N-[3-(6-propan-2-yloxy-3-pyridinyl)-1H-indazol-5-yl]pyrrolidine-3-carboxamide C37H41N9O3S

Also listed as

MK-8353, 95% AmBeed CAS 1184173-73-6
MK-8353/ 96.15% (existing batch purity) TargetMol CAS 1184173-73-6
MK8353 GLPBio CAS 1184173-73-6
(3S)-1-[2-[3,6-Dihydro-4-[4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl]-1(2H)-pyridinyl]-2-oxoethyl]-N-[3-[6-(1-methylethoxy)-3-pyridinyl]-1H-indazol-5-yl]-3-(methylthio)-3-pyrrolidinecarboxamide, 99%, 99% Chemat CAS 1184173-73-6
MK-8353, 99.94% MedChemExpress CAS 1184173-73-6