N-(Cyanomethyl)-4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]benzamide, 98+%
cas: 1056634-68-4 — see every product listed under this CAS number, including other names
N-(Cyanomethyl)-4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]benzamide, 98+% (CAS 1056634-68-4) is a chemical reagent available from Chemat. Available pack sizes: 5mg, 10mg, 50mg, 100mg, 250mg, 1g. Offered by: Chemat.
| brand | Chemat |
|---|---|
| catalog number | Ch11499S-5mg |
| cas | 1056634-68-4 |
| size | 5mg |
| availability | 2g |
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Available pack sizes
| brand | size | price | |
|---|---|---|---|
| Chemat | 5mg | 122.00 Pln | |
| Chemat | 10mg | 170.00 Pln | |
| Chemat | 50mg | 482.00 Pln | |
| Chemat | 100mg | 731.60 Pln | |
| Chemat | 250mg | 1278.80 Pln | |
| Chemat | 1g | 3342.80 Pln |
properties
| purity | 98+% |
|---|---|
| delivery time | 3 weeks |
Momelotinib is a benzamide obtained by formal condensation of the carboxy group of 4-{2-[4-(morpholin-4-yl)anilino]pyrimidin-4-yl}benzoic acid with the primary amino group of aminoacetonitrile. It is an ATP-competitive JAK1/JAK2 inhibitor with IC50 of 11 nM and 18 nM, respectively. Used for the treatment of patients with intermediate- or high-risk myelofibrosis. It has a role as an antineoplastic agent, an apoptosis inducer, an anti-anaemic agent and an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor. It is a nitrile, a member of benzamides, an aminopyrimidine, a member of morpholines, a secondary amino compound and a tertiary amino compound.
Source: ChEBI
| Molecular formula | C23H22N6O2 |
|---|---|
| Molecular weight | 414.5 g/mol |
| IUPAC name | N-(cyanomethyl)-4-[2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]benzamide |
| InChIKey | ZVHNDZWQTBEVRY-UHFFFAOYSA-N |
| SMILES | C1COCCN1C2=CC=C(C=C2)NC3=NC=CC(=N3)C4=CC=C(C=C4)C(=O)NCC#N |
Computed by PubChem (NCBI)
Synonyms:
MOMELOTINIB, Cyt387, Cyt-387, N-(Cyanomethyl)-4-(2-((4-morpholinophenyl)amino)pyrimidin-4-yl)benzamide, momelotinibum, N-(cyanomethyl)-4-[2-[[4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]benzamide, N-(cyanomethyl)-4-(2-{[4-(morpholin-4-yl)phenyl]amino}pyrimidin-4-yl)benzamide, N-(cyanomethyl)-4-(2-((4-(4-morpholinyl)phenyl)amino)-4-pyrimidinyl)benzamide, N-(Cyanomethyl)-4-(2-((4-(morpholin-4-yl)phenyl)amino)pyrimidin-4-yl)benzamide, N-(cyanomethyl)-4-[2-(4-morpholinoanilino)pyrimidin-4-yl]benzamide