cas: 943319-70-8 — see every product listed under this CAS number, including other names
Ponatinib, 99.67% (CAS 943319-70-8) is a chemical reagent available from Chemat. Available pack sizes: 50 mg, 10 mg, 100 mg, 5 mg, 10mM/1mL. Offered by: MedChemExpress.
| brand | MedChemExpress |
|---|---|
| catalog number | HY-12047-50 mg |
| cas | 943319-70-8 |
| size | 50 mg |
| availability | Get quote |
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| brand | size | price | |
|---|---|---|---|
| MedChemExpress | 50 mg | 593.69 Pln | |
| MedChemExpress | 10 mg | 435.79 Pln | |
| MedChemExpress | 100 mg | 876.97 Pln | |
| MedChemExpress | 5 mg | 319.69 Pln | |
| MedChemExpress | 10mM/1mL | 468.30 Pln |
| delivery time | over 3 weeks |
|---|---|
| purity | 99.67% |
Ponatinib is a benzamide obtained by the formal condensation of the carboxy group of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzoic acid with the anilino group of 4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)aniline. It is a multi-target tyrosine kinase inhibitor that targets ABL, SRC, FGFR, and others and was designed to overcome the resistance of BCR-ABL mutation to imatinib, in particular the gatekeeper mutation ABLT315I. It has a role as an antineoplastic agent and a tyrosine kinase inhibitor. It is a member of benzamides, a N-methylpiperazine, an imidazopyridazine, an acetylenic compound and a member of (trifluoromethyl)benzenes. It is a conjugate base of a ponatinib(1+).
Source: ChEBI
| Molecular formula | C29H27F3N6O |
|---|---|
| Molecular weight | 532.6 g/mol |
| IUPAC name | 3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide |
| InChIKey | PHXJVRSECIGDHY-UHFFFAOYSA-N |
| SMILES | CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5 |
Computed by PubChem (NCBI)