TGF-╬▓ RI Kinase Inhibitor II 1PC X 2MG

cas: 446859-33-2 — see every product listed under this CAS number, including other names

TGF-╬▓ RI Kinase Inhibitor II 1PC X 2MG (CAS 446859-33-2) is a chemical reagent available from Chemat. Available pack sizes: 2MG. Offered by: Sigma-Aldrich.

brandSigma-Aldrich
catalog number616452-2MG
cas446859-33-2
size2MG
availability availability
Documents: Safety Data Sheet (MSDS)
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Available pack sizes

brand size price
Sigma-Aldrich 2MG 839.00 Pln

properties

purityNo data
delivery time1-2 weeks (only if in stock, to check click on availability)
Structural formula: {0} (CAS {1})

RepSox is a member of the class of pyrazoles that is 1H-pyrazole substituted by 6-methylpyridin-2-yl and 1,5-naphthyridin-2-yl groups at positions 3 and 4, respectively. It is a potent and selective inhibitor of TGF-beta R1 kinase (IC50 = 4 nM) and ALK5 autophosphorylation and binding (IC50 = 23 nM). It has a role as an antineoplastic agent, a bone density conservation agent, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor and a TGFbeta receptor antagonist. It is a member of pyrazoles, a member of pyridines and a 1,5-naphthyridine derivative.

Source: ChEBI

Identity
Molecular formulaC17H13N5
Molecular weight287.32 g/mol
IUPAC name2-[5-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine
InChIKeyLBPKYPYHDKKRFS-UHFFFAOYSA-N
SMILESCC1=NC(=CC=C1)C2=C(C=NN2)C3=NC4=C(C=C3)N=CC=C4

Computed by PubChem (NCBI)

Synonyms: RepSox, 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine, 2-[5-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]-1,5-naphthyridine, Alk 5 Inhibitor II, RepSox (GMP), 2-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine, 1,5-Naphthyridine, 2-[3-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]-, Tox21_500541, 2-(3-(6-Methylpyridine-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine, 2-[3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]-1,5-naphthyridine
Isomers (same molecular formula)
4-phenyl-2,6-di(pyrazol-1-yl)pyridine C17H13N5
6-[5-(6-methyl-2-pyridinyl)-1H-pyrazol-4-yl]quinoxaline C17H13N5
N,1-diphenylpyrazolo[3,4-d]pyrimidin-4-amine C17H13N5

Also listed as

2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine, 98% Fluorochem CAS 446859-33-2
Alk 5 Inhibitor II, >95% (HPLC) TRC CAS 446859-33-2
RepSox/ 99.62% (existing batch purity) TargetMol CAS 446859-33-2
RepSox GLPBio CAS 446859-33-2
RepSox, >98.0%(HPLC) TCI CAS 446859-33-2
TGF-╬▓ RI Kinase Inhibitor II 1PC X 200MG Sigma-Aldrich CAS 446859-33-2
RepSox, 99.92% MedChemExpress CAS 446859-33-2
RepSox (GMP) MedChemExpress CAS 446859-33-2
RepSox (Standard) MedChemExpress CAS 446859-33-2
RepSox, 98% Ambeed CAS 446859-33-2