Products 1062172-60-4
CAS 1062172-60-4 appears in our catalog under these names: Methyl 4-(6-(4-(3-(4-(hydroxymethyl)phenyl)ureido)phenyl)-4-morpholino-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate, 98%, 98%, Compound 28, Compound 28, mTOR inhibitor WYE-28, 99.75%. Offered by: Chemat, TargetMol, GLPBio, MedChemExpress. Available pack sizes: 10mg, 5mg, 1mg, 500ug, 500μg, 10 mg, 25 mg, 5 mg.
WYE-28 is a pyrazolopyrimidine that is 1H-pyrazolo[3,4-d]pyrimidine substituted by 1-(methoxycarbonyl)piperidin-4-yl, morpholin-4-yl and 4-({[4-(hydroxymethyl)phenyl]carbamoyl}amino)phenyl groups at positions 1, 4, and 6, respectively. It is a potent inhibitor of mTOR (IC50 = 0.08 nM) and PI3Kalpha (IC50 = 6 nM). It has a role as an antineoplastic agent, an EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor and a mTOR inhibitor. It is a member of phenylureas, a member of benzyl alcohols, a carbamate ester, an aromatic primary alcohol, a pyrazolopyrimidine, a member of morpholines and a piperidinecarboxylate ester.
Source: ChEBI
| Molecular formula | C30H34N8O5 |
|---|---|
| Molecular weight | 586.6 g/mol |
| IUPAC name | methyl 4-[6-[4-[[4-(hydroxymethyl)phenyl]carbamoylamino]phenyl]-4-morpholin-4-ylpyrazolo[5,4-d]pyrimidin-1-yl]piperidine-1-carboxylate |
| InChIKey | DLIGFKRUAOAIBA-UHFFFAOYSA-N |
| SMILES | COC(=O)N1CCC(CC1)N2C3=C(C=N2)C(=NC(=N3)C4=CC=C(C=C4)NC(=O)NC5=CC=C(C=C5)CO)N6CCOCC6 |
Computed by PubChem (NCBI)