Products 226927-89-5
CAS 226927-89-5 is the registry number for LB42908. Offered by: MedChemExpress. Available pack sizes: Get quote.
LB42908 is a member of the class of pyrrolecarboxamides that is 1H-pyrrole substituted by [1-(3a,7a-dihydro-1,3-benzodioxol-5-ylmethyl)-1H-imidazol-5-yl]methyl, (4-methylpiperazin-1-yl)carbonyl, and naphthalen-1-yl groups at positions 1, 3 and 4, respectively. It is a potent inhibitor of Ras farnesyltransferase (IC50= 0.9nM against H-Ras and 2.4nM against K-Ras) with potential anticancer activity. It has a role as an antineoplastic agent, an EC 2.5.1.58 (protein farnesyltransferase) inhibitor and an apoptosis inducer. It is a member of imidazoles, a member of naphthalenes, a benzodioxole, a N-acylpiperazine, a N-methylpiperazine and a pyrrolecarboxamide.
Source: ChEBI
| Molecular formula | C32H33N5O3 |
|---|---|
| Molecular weight | 535.6 g/mol |
| IUPAC name | [1-[[3-(3a,7a-dihydro-1,3-benzodioxol-5-ylmethyl)imidazol-4-yl]methyl]-4-naphthalen-1-ylpyrrol-3-yl]-(4-methylpiperazin-1-yl)methanone |
| InChIKey | VZWZHIJGBPHRDI-UHFFFAOYSA-N |
| SMILES | CN1CCN(CC1)C(=O)C2=CN(C=C2C3=CC=CC4=CC=CC=C43)CC5=CN=CN5CC6=CC7C(C=C6)OCO7 |
Computed by PubChem (NCBI)