17–AAG (KOS953)
cas: 75747-14-7 — see every product listed under this CAS number, including other names
17–AAG (KOS953) (CAS 75747-14-7) is a chemical reagent available from Chemat. Available pack sizes: 10mg, 100mg, 200mg, 10mM (in 1ml dmso), 50mg. Offered by: GLPBio.
| brand | GLPBio |
|---|---|
| catalog number | GC11720-10 |
| cas | 75747-14-7 |
| size | 10mg |
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Available pack sizes
| brand | size | price | |
|---|---|---|---|
| GLPBio | 10mg | 629.80 Pln | |
| GLPBio | 100mg | 1219.55 Pln | |
| GLPBio | 200mg | 1584.63 Pln | |
| GLPBio | 10mM (in 1ml dmso) | 634.48 Pln | |
| GLPBio | 50mg | 1027.65 Pln |
properties
| purity | No data |
|---|---|
| delivery time | To be confirmed by Chemat |
Tanespimycin is a 19-membered macrocyle that is geldanamycin in which the methoxy substituent attached to the benzoquinone moiety has been replaced by an allylamino group. It is a potent inhibitor of heat shock protein 90 (Hsp90). A less toxic analogue than geldanamycin, it induces apoptosis and displays antitumour effects. It has a role as an antineoplastic agent, a Hsp90 inhibitor and an apoptosis inducer. It is a member of 1,4-benzoquinones, an ansamycin, a carbamate ester, an organic heterobicyclic compound and a secondary amino compound. It is functionally related to a geldanamycin.
Source: ChEBI
| Molecular formula | C31H43N3O8 |
|---|---|
| Molecular weight | 585.7 g/mol |
| IUPAC name | [(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-19-(prop-2-enylamino)-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl] carbamate |
| InChIKey | AYUNIORJHRXIBJ-TXHRRWQRSA-N |
| SMILES | C[C@H]1C[C@@H]([C@@H]([C@H](/C=C(/[C@@H]([C@H](/C=C\C=C(\C(=O)NC2=CC(=O)C(=C(C1)C2=O)NCC=C)/C)OC)OC(=O)N)\C)C)O)OC |
Computed by PubChem (NCBI)
Synonyms:
Tanespimycin, 17-(Allylamino)-17-demethoxygeldanamycin, 17-(Allylamino)geldanamycin, tanespimycine, tanespimicina, tanespimycinum, 17-Demethoxy-17-allylamino geldanamycin, 17-demethoxy-17-(2-propenylamino)geldanamycin, Geldanamycin, 17-demethoxy-17-(2-propenylamino)-, 17-N-allylamino-17-demethoxygeldanamycin