5-aza-4'-thio-2'-deoxycytidine
cas: 169514-76-5 — see every product listed under this CAS number, including other names
5-aza-4'-thio-2'-deoxycytidine (CAS 169514-76-5) is a chemical reagent available from Chemat. Available pack sizes: on request. Offered by: Chemat Brand.
| brand | Chemat Brand |
|---|---|
| catalog number | ULC4546 |
| cas | 169514-76-5 |
| size | on request |
| availability | Do potwierdzenia przez Chemat|To be confirmed by Chemat |
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Available pack sizes
| brand | size | price | |
|---|---|---|---|
| Chemat Brand | on request | price on request |
properties
| purity | No data |
|---|---|
| category | Chemicals |
| delivery time | To be confirmed by Chemat |
NTX-301 is 5-Aza-4'-thio-2'-deoxycytidine is an orally bioavailable, nucleoside analog and DNA methyltransferase I (DNMT1) inhibitor, with potential DNA hypomethylating and antineoplastic activities. Upon administration, 5-aza-4'-thio-2'-deoxycytidine (Aza-TdC) gets incorporated into DNA, where it binds to the active site of DNMT1, a maintenance methyltransferase that contributes to the hypermethylation and silencing of tumor suppressor genes. The formation of covalent DNMT1-DNA complexes inhibits DNMT1, prevents DNA methylation of CpG sites, causes CpG demethylation, and results in the re-expression and re-activation of silenced tumor suppressor genes. This inhibits tumor cell proliferation. DNMT1, overactivated in tumor cells, plays a key role in tumor cell proliferation.
Source: ChEBI
| Molecular formula | C8H12N4O3S |
|---|---|
| Molecular weight | 244.27 g/mol |
| IUPAC name | 4-amino-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)thiolan-2-yl]-1,3,5-triazin-2-one |
| InChIKey | HOOZQNOZVFCJNL-KVQBGUIXSA-N |
| SMILES | C1[C@@H]([C@H](S[C@H]1N2C=NC(=NC2=O)N)CO)O |
Computed by PubChem (NCBI)