Products 169514-76-5
CAS 169514-76-5 appears in our catalog under these names: 5-aza-4'-thio-2'-deoxycytidine, 5–Aza–4'–thio–2'–deoxycytidine, 5-Aza-4'-thio-2'-deoxycytidine, 99.09%. Offered by: Chemat Brand, GLPBio, MedChemExpress. Available pack sizes: on request, 1mg, 10 mg, 100 mg, 5 mg, 50 mg, 25 mg.
NTX-301 is 5-Aza-4'-thio-2'-deoxycytidine is an orally bioavailable, nucleoside analog and DNA methyltransferase I (DNMT1) inhibitor, with potential DNA hypomethylating and antineoplastic activities. Upon administration, 5-aza-4'-thio-2'-deoxycytidine (Aza-TdC) gets incorporated into DNA, where it binds to the active site of DNMT1, a maintenance methyltransferase that contributes to the hypermethylation and silencing of tumor suppressor genes. The formation of covalent DNMT1-DNA complexes inhibits DNMT1, prevents DNA methylation of CpG sites, causes CpG demethylation, and results in the re-expression and re-activation of silenced tumor suppressor genes. This inhibits tumor cell proliferation. DNMT1, overactivated in tumor cells, plays a key role in tumor cell proliferation.
Source: ChEBI
| Molecular formula | C8H12N4O3S |
|---|---|
| Molecular weight | 244.27 g/mol |
| IUPAC name | 4-amino-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)thiolan-2-yl]-1,3,5-triazin-2-one |
| InChIKey | HOOZQNOZVFCJNL-KVQBGUIXSA-N |
| SMILES | C1[C@@H]([C@H](S[C@H]1N2C=NC(=NC2=O)N)CO)O |
Computed by PubChem (NCBI)