ARS-1620

cas: 1698024-73-5 — see every product listed under this CAS number, including other names

ARS-1620 (CAS 1698024-73-5) is a chemical reagent available from Chemat. Available pack sizes: 10mg, 50mg, 25mg. Offered by: Biosynth.

brandBiosynth
catalog numberYSC02473-10mg
cas1698024-73-5
size10mg
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properties

categoryLife Sciences
sub-category 1Ligands
purityNo data
delivery time3-4 Weeks
Structural formula: {0} (CAS {1})

ARS-1620 is a qinazoline derivative carrying chloro and fluoro substituents at positions 6 and 8 respectively, a 2-fluoro-6-hydroxyphenyl group at position 7, and a 4-(prop-2-enoyl)piperazin-1-yl group at position 4. A potent, selective, and orally bioavailable covalent KRAS-G12C inhibitor, it inhibits the protein coding gene KRAS (Kirsten rat sarcoma virus) with high potency in cells and animals. It has a role as an antiviral agent, an inhibitor and an antineoplastic agent.

Source: ChEBI

Identity
Molecular formulaC21H17ClF2N4O2
Molecular weight430.8 g/mol
IUPAC name1-[4-[6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl]piperazin-1-yl]prop-2-en-1-one
InChIKeyZRPZPNYZFSJUPA-UHFFFAOYSA-N
SMILESC=CC(=O)N1CCN(CC1)C2=NC=NC3=C(C(=C(C=C32)Cl)C4=C(C=CC=C4F)O)F

Computed by PubChem (NCBI)

Synonyms: C21H17ClF2N4O2, orb1299662, orb1309979, orb1309980, ZRPZPNYZFSJUPA-UHFFFAOYSA-N, s8707, example 227 [US9840516B2]
Related forms of this compound
1-[4-[6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl]piperazin-1-yl]prop-2-en-1-one C21H17ClF2N4O2
1-[4-[6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl]piperazin-1-yl]prop-2-en-1-one C21H17ClF2N4O2

Also listed as

ARS-1323/ 98.88% (existing batch purity) TargetMol CAS 1698024-73-5
ARS-1323, 99.67% MedChemExpress CAS 1698024-73-5
ARS-1323 Chemat CAS 1698024-73-5