Products 1698055-85-4

CAS 1698055-85-4 appears in our catalog under these names: ARS-1620/ 98%, ARS-1620, 99.59%, ARS-1620, 99%, (S)-1-(4-(6-Chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl)piperazin-1-yl)prop-2-en-1-one, 99%, 1-[4-[(7S)-6-Chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)-4-quinazolinyl]-1-piperazinyl]-2-propen-1-one, 99%. Offered by: TargetMol, MedChemExpress, Ambeed, BLDpharm, Chemat. Available pack sizes: 1mg, 2mg, 5mg, 10mg, 25mg, 50mg, 100mg, 10 mg.

ARS-1620/ 98%
TargetMol
  • size: 1mg, 2mg, 5mg, 10mg
  • Variants: 7
from 724.90
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ARS-1620, 99.59%
MedChemExpress
  • size: 10 mg, 100 mg, 10mM/1mL, 5 mg
  • Variants: 6
from 598.33
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ARS-1620, 99%
Ambeed
  • size: 100mg, 250mg
  • Variants: 2
from 2328.38
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(S)-1-(4-(6-Chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl)piperazin-1-yl)prop-2-en-1-one, 99%
BLDpharm
  • size: 1mg, 5mg, 10mg, 25mg
  • Variants: 7
from 208.84
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1-[4-[(7S)-6-Chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)-4-quinazolinyl]-1-piperazinyl]-2-propen-1-one, 99%
Chemat
  • size: 1mg, 5mg, 10mg, 25mg
  • Variants: 7
from 150.80
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Structural formula: {0} (CAS {1})

ARS-1620 is a qinazoline derivative carrying chloro and fluoro substituents at positions 6 and 8 respectively, a 2-fluoro-6-hydroxyphenyl group at position 7, and a 4-(prop-2-enoyl)piperazin-1-yl group at position 4. A potent, selective, and orally bioavailable covalent KRAS-G12C inhibitor, it inhibits the protein coding gene KRAS (Kirsten rat sarcoma virus) with high potency in cells and animals. It has a role as an antiviral agent, an inhibitor and an antineoplastic agent.

Source: ChEBI

Identity
Molecular formulaC21H17ClF2N4O2
Molecular weight430.8 g/mol
IUPAC name1-[4-[6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl]piperazin-1-yl]prop-2-en-1-one
InChIKeyZRPZPNYZFSJUPA-UHFFFAOYSA-N
SMILESC=CC(=O)N1CCN(CC1)C2=NC=NC3=C(C(=C(C=C32)Cl)C4=C(C=CC=C4F)O)F

Computed by PubChem (NCBI)

Synonyms: C21H17ClF2N4O2, orb1299662, orb1309979, orb1309980, ZRPZPNYZFSJUPA-UHFFFAOYSA-N, s8707, example 227 [US9840516B2]
Related forms of this compound
1-[4-[6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl]piperazin-1-yl]prop-2-en-1-one C21H17ClF2N4O2
1-[4-[6-chloro-8-fluoro-7-(2-fluoro-6-hydroxyphenyl)quinazolin-4-yl]piperazin-1-yl]prop-2-en-1-one C21H17ClF2N4O2