Binimetinib, 98%
cas: 606143-89-9 — see every product listed under this CAS number, including other names
Binimetinib, 98% (CAS 606143-89-9) is a chemical reagent available from Chemat. Available pack sizes: 100MG, 50mg, 250mg, 1g. Offered by: Thermo Scientific (Acros), Fluorochem.
| brand | Thermo Scientific (Acros) |
|---|---|
| catalog number | 474821000 |
| cas | 606143-89-9 |
| size | 100MG |
| availability | availability |
Documents:
Safety Data Sheet (MSDS)
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Available pack sizes
| brand | size | price | |
|---|---|---|---|
| Thermo Scientific (Acros) | 100MG | 890.89 Pln | |
| Fluorochem | 50mg | 799.74 Pln | |
| Fluorochem | 100mg | 1304.77 Pln | |
| Fluorochem | 250mg | 2372.10 Pln | |
| Fluorochem | 1g | 8994.77 Pln |
properties
| delivery time | 2-3 weeks |
|---|---|
| category | Chemicals |
| purity | 98% |
Binimetinib is a member of the class of benzimidazoles that is 1-methyl-1H-benzimidazole which is substituted at positions 4, 5, and 6 by fluorine, (4-bromo-2-fluorophenyl)nitrilo, and N-(2-hydroxyethoxy)aminocarbonyl groups, respectively. It is a MEK1 and MEK2 inhibitor (IC50= 12 nM). Approved by the FDA for the treatment of patients with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation in combination with encorafenib. It has a role as an antineoplastic agent, an apoptosis inducer and an EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor. It is a member of benzimidazoles, a member of bromobenzenes, a secondary amino compound, a hydroxamic acid ester and a member of monofluorobenzenes.
Source: ChEBI
| Molecular formula | C17H15BrF2N4O3 |
|---|---|
| Molecular weight | 441.2 g/mol |
| IUPAC name | 6-(4-bromo-2-fluoroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide |
| InChIKey | ACWZRVQXLIRSDF-UHFFFAOYSA-N |
| SMILES | CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)F)C(=O)NOCCO |
Computed by PubChem (NCBI)