Products 606143-89-9
CAS 606143-89-9 appears in our catalog under these names: Mek162, 95%, Binimetinib (MEK-162), MEK 162, >95% (HPLC), Binimetinib/ 98.03% (existing batch purity), MEK162 (ARRY–162, ARRY–438162). Offered by: Combi-blocks, Chemat Brand, TRC, TargetMol, GLPBio. Available pack sizes: 250mg, 1g, 100mg, on request, 10mg, 50mg, 5mg, 25mg.
Binimetinib is a member of the class of benzimidazoles that is 1-methyl-1H-benzimidazole which is substituted at positions 4, 5, and 6 by fluorine, (4-bromo-2-fluorophenyl)nitrilo, and N-(2-hydroxyethoxy)aminocarbonyl groups, respectively. It is a MEK1 and MEK2 inhibitor (IC50= 12 nM). Approved by the FDA for the treatment of patients with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation in combination with encorafenib. It has a role as an antineoplastic agent, an apoptosis inducer and an EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor. It is a member of benzimidazoles, a member of bromobenzenes, a secondary amino compound, a hydroxamic acid ester and a member of monofluorobenzenes.
Source: ChEBI
| Molecular formula | C17H15BrF2N4O3 |
|---|---|
| Molecular weight | 441.2 g/mol |
| IUPAC name | 6-(4-bromo-2-fluoroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide |
| InChIKey | ACWZRVQXLIRSDF-UHFFFAOYSA-N |
| SMILES | CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)F)C(=O)NOCCO |
Computed by PubChem (NCBI)