Products 252935-94-7
CAS 252935-94-7 appears in our catalog under these names: CHIR-98014/ 97.09% (existing batch purity), CHIR–98014, CHIR-98014 98%, CHIR-98014, 98%, 98%, CHIR-98014, 98.44%. Offered by: TargetMol, GLPBio, Ambeed, Chemat, MedChemExpress. Available pack sizes: 5mg, 10mg, 25mg, 50mg, 100mg, 200mg, 10mM (in 1ml dmso), 1mg.
CHIR-98014 is a member of the class of aminopyrimidines that is pyrimidine substituted by {2-[(6-amino-5-nitropyridin-2-yl)amino]ethyl}amino, 2,4-dichlorophenyl, and 1H-imidazol-1-yl groups at positions 2, 4 and 5, respectively. It is a potent ATP-competitive inhibitor of GSK3alpha and GSK3beta (IC50 values of 0.65 and 0.58 nM, respectively). It has a role as a Wnt signalling activator, a tau aggregation inhibitor, a hypoglycemic agent, an antineoplastic agent, an apoptosis inducer and an EC 2.7.11.26 (tau-protein kinase) inhibitor. It is a dichlorobenzene, a member of imidazoles, a C-nitro compound, an aminopyrimidine, a secondary amino compound and a diaminopyridine.
Source: ChEBI
| Molecular formula | C20H17Cl2N9O2 |
|---|---|
| Molecular weight | 486.3 g/mol |
| IUPAC name | 6-N-[2-[[4-(2,4-dichlorophenyl)-5-imidazol-1-ylpyrimidin-2-yl]amino]ethyl]-3-nitropyridine-2,6-diamine |
| InChIKey | MDZCSIDIPDZWKL-UHFFFAOYSA-N |
| SMILES | C1=CC(=C(C=C1Cl)Cl)C2=NC(=NC=C2N3C=CN=C3)NCCNC4=NC(=C(C=C4)[N+](=O)[O-])N |
Computed by PubChem (NCBI)