CM-272

cas: 1846570-31-7 — see every product listed under this CAS number, including other names

CM-272 (CAS 1846570-31-7) is a chemical reagent available from Chemat. Available pack sizes: 50mg, 25mg, 100mg. Offered by: Biosynth.

brandBiosynth
catalog numberWYC57031-50mg
cas1846570-31-7
size50mg
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Available pack sizes

brand size price
Biosynth 50mg price on request
Biosynth 25mg price on request
Biosynth 100mg price on request

properties

categoryLife Sciences
sub-category 1Ligands
purityNo data
delivery time3-4 Weeks
Structural formula: {0} (CAS {1})

CM-272 is a member of the class of aminoquinolines that is is quinoline substituted by 5-methylfuran-2-yl, (1-methylpiperidin-4-yl)amino, methoxy, and 3-(pyrrolidin-1-yl)propoxy groups at positions 2, 4, 6 and 7, respectively. It is a dual G9a/DNA methyltransferases inhibitor with antitumor activity. It inhibits G9a, DNMT1, DNMT3A, DNMT3B and GLP (IC50 = 8 nM, 382 nM, 85 nM, 1200 nM and 2 nM, respectively). It has a role as an EC 2.1.1.43 (enhancer of zeste homolog 2) inhibitor, a ferroptosis inducer, an antineoplastic agent, an apoptosis inducer and an EC 2.1.1.37 [DNA (cytosine-5-)-methyltransferase] inhibitor. It is a member of furans, a member of piperidines, an aromatic ether, an aminoquinoline, a N-alkylpyrrolidine, a diether, a secondary amino compound and a tertiary amino compound.

Source: ChEBI

Identity
Molecular formulaC28H38N4O3
Molecular weight478.6 g/mol
IUPAC name6-methoxy-2-(5-methylfuran-2-yl)-N-(1-methylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amine
InChIKeyRLQLKZTYUYIWDB-UHFFFAOYSA-N
SMILESCC1=CC=C(O1)C2=NC3=CC(=C(C=C3C(=C2)NC4CCN(CC4)C)OC)OCCCN5CCCC5

Computed by PubChem (NCBI)

Synonyms: 1846570-31-7 (free base), orb1225855, orb1299991, s8812

Also listed as

CM–272 GLPBio CAS 1846570-31-7
CM-272/ 98.21% (existing batch purity) TargetMol CAS 1846570-31-7
CM-272, 98.70% MedChemExpress CAS 1846570-31-7
CM-272 (Standard) MedChemExpress CAS 1846570-31-7
CM-272, 98% Ambeed CAS 1846570-31-7
6-Methoxy-2-(5-methylfuran-2-yl)-N-(1-methylpiperidin-4-yl)-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-amine, 98% BLDpharm CAS 1846570-31-7
6-methoxy-2-(5-methyl-2-furanyl)-N-(1-methyl-4-piperidinyl)-7-[3-(1-pyrrolidinyl)propoxy]-4-quinolinamine, 98% 6-methoxy-2-(5-methyl-2-furanyl)-N-(1-methyl-4-piperidinyl)-7-[3-(1-pyrrolidinyl)propoxy]-4-quinolinamine, 98% Fluorochem CAS 1846570-31-7