Products 1846570-31-7
CAS 1846570-31-7 appears in our catalog under these names: CM–272, CM-272/ 98.21% (existing batch purity), CM-272, CM-272 98%, 6-Methoxy-2-(5-methylfuran-2-yl)-N-(1-methylpiperidin-4-yl)-7-(3-(pyrrolidin-1-yl)propoxy)quinolin-4-amine, 98%, 98%. Offered by: GLPBio, TargetMol, Biosynth, Ambeed, Chemat. Available pack sizes: 1g, 25mg, 5mg, 500mg, 1mg, 10mg, 50mg, 100mg.
CM-272 is a member of the class of aminoquinolines that is is quinoline substituted by 5-methylfuran-2-yl, (1-methylpiperidin-4-yl)amino, methoxy, and 3-(pyrrolidin-1-yl)propoxy groups at positions 2, 4, 6 and 7, respectively. It is a dual G9a/DNA methyltransferases inhibitor with antitumor activity. It inhibits G9a, DNMT1, DNMT3A, DNMT3B and GLP (IC50 = 8 nM, 382 nM, 85 nM, 1200 nM and 2 nM, respectively). It has a role as an EC 2.1.1.43 (enhancer of zeste homolog 2) inhibitor, a ferroptosis inducer, an antineoplastic agent, an apoptosis inducer and an EC 2.1.1.37 [DNA (cytosine-5-)-methyltransferase] inhibitor. It is a member of furans, a member of piperidines, an aromatic ether, an aminoquinoline, a N-alkylpyrrolidine, a diether, a secondary amino compound and a tertiary amino compound.
Source: ChEBI
| Molecular formula | C28H38N4O3 |
|---|---|
| Molecular weight | 478.6 g/mol |
| IUPAC name | 6-methoxy-2-(5-methylfuran-2-yl)-N-(1-methylpiperidin-4-yl)-7-(3-pyrrolidin-1-ylpropoxy)quinolin-4-amine |
| InChIKey | RLQLKZTYUYIWDB-UHFFFAOYSA-N |
| SMILES | CC1=CC=C(O1)C2=NC3=CC(=C(C=C3C(=C2)NC4CCN(CC4)C)OC)OCCCN5CCCC5 |
Computed by PubChem (NCBI)