Carfilzomib (PR–171)

cas: 868540-17-4 — see every product listed under this CAS number, including other names

Carfilzomib (PR–171) (CAS 868540-17-4) is a chemical reagent available from Chemat. Available pack sizes: 10mg, 25mg, 5mg, 10mM (in 1ml dmso). Offered by: GLPBio.

brandGLPBio
catalog numberGC15089-10
cas868540-17-4
size10mg
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Available pack sizes

brand size price
GLPBio 10mg 671.93 Pln
GLPBio 25mg 817.02 Pln
GLPBio 5mg 587.68 Pln
GLPBio 10mM (in 1ml dmso) 639.16 Pln

properties

purityNo data
delivery timeTo be confirmed by Chemat
Structural formula: {0} (CAS {1})

Carfilzomib is a synthetic tetrapeptide consisting of morpholin-4-acetyl, L-2-amino-4-phenylbutanoyl, L-leucyl and L-phenylalanyl residues joined in sequence with the C-terminus connected to the amino group of (2S)-2-amino-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-1-one via an amide linkage. Used for the treatment of patients with multiple myeloma. It has a role as an antineoplastic agent and a proteasome inhibitor. It is an epoxide, a member of morpholines and a tetrapeptide.

Source: ChEBI

Identity
Molecular formulaC40H57N5O7
Molecular weight719.9 g/mol
IUPAC name(2S)-4-methyl-N-[(2S)-1-[[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]-4-phenylbutanoyl]amino]pentanamide
InChIKeyBLMPQMFVWMYDKT-NZTKNTHTSA-N
SMILESCC(C)C[C@@H](C(=O)[C@]1(CO1)C)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC3=CC=CC=C3)NC(=O)CN4CCOCC4

Computed by PubChem (NCBI)

Synonyms: Carfilzomib, Kyprolis, carfilzomibum, Carfilzomib (PR-171), Carfilzomib (PR171), Carfilzomib [USAN], Carfilzomib [USAN:INN], CarfilzoMib salt, Kyprolis (TN), Carfilzomib; PR171
Related forms of this compound
(2R)-4-methyl-N-[(2S)-1-[[(2R)-4-methyl-1-[(2S)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-2-[[(2R)-2-[(2-morpholin-4-ylacetyl)amino]-4-phenylbutanoyl]amino]pentanamide C40H57N5O7
(2R)-4-methyl-N-[(2S)-1-[[4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-2-[[(2R)-2-[(2-morpholin-4-ylacetyl)amino]-4-phenylbutanoyl]amino]pentanamide C40H57N5O7
(2R)-4-methyl-N-[(2S)-1-[[4-methyl-1-[(2S)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-2-[[(2R)-2-[(2-morpholin-4-ylacetyl)amino]-4-phenylbutanoyl]amino]pentanamide C40H57N5O7
(2S)-4-methyl-N-[(2R)-1-[[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]-4-phenylbutanoyl]amino]pentanamide C40H57N5O7
(2S)-4-methyl-N-[(2S)-1-[[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-2-[[(2R)-2-[(2-morpholin-4-ylacetyl)amino]-4-phenylbutanoyl]amino]pentanamide C40H57N5O7
(2R)-4-methyl-N-[(2S)-1-[[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]-4-phenylbutanoyl]amino]pentanamide C40H57N5O7
(2S)-4-methyl-N-[(2S)-1-[[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-2-[[(2S)-2-[[2-(2,2,3,3,5,5,6,6-octadeuteriomorpholin-4-yl)acetyl]amino]-4-phenylbutanoyl]amino]pentanamide C40H57N5O7
(2R)-4-methyl-N-[(2S)-1-[[(2S)-4-methyl-1-[(2S)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-2-[[(2R)-2-[(2-morpholin-4-ylacetyl)amino]-4-phenylbutanoyl]amino]pentanamide C40H57N5O7

Also listed as

Carfilzomib Chemat Brand CAS 868540-17-4
Carfilzomib, >95% (HPLC) TRC CAS 868540-17-4
Carfilzomib/ 99.84% (existing batch purity) TargetMol CAS 868540-17-4
Carfilzomib, 98.00% Chemat CAS 868540-17-4
Carfilzomib, 98% Thermo Scientific (Acros) CAS 868540-17-4
(αS)-α-[[2-(4-Morpholinyl)acetyl]amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-L-phenylalaninamide, 98%, 98% Chemat CAS 868540-17-4
Carfilzomib, 99.98% MedChemExpress CAS 868540-17-4
Carfilzomib (Standard), 99.98% MedChemExpress CAS 868540-17-4