Products 868540-17-4

CAS 868540-17-4 appears in our catalog under these names: Carfilzomib, Carfilzomib, >95% (HPLC), Carfilzomib/ 99.84% (existing batch purity), Carfilzomib (PR–171), Carfilzomib, 98.00%. Offered by: Chemat Brand, Hubei YoungXin, Mikromol, TRC, TargetMol. Available pack sizes: on request, 10mg, 25mg, 50mg, 100mg, 200mg, 250mg, 5mg.

Carfilzomib
Chemat Brand, Hubei YoungXin, Mikromol
  • size: on request, 10mg, 25mg, 50mg
  • Variants: 12
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Carfilzomib, >95% (HPLC)
TRC
  • size: 10mg, 250mg, 5mg
  • Variants: 3
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Carfilzomib/ 99.84% (existing batch purity)
TargetMol
  • size: 5mg, 10mg, 25mg, 50mg
  • Variants: 5
from 499.07
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Carfilzomib (PR–171)
GLPBio
  • size: 10mg, 25mg, 5mg, 10mM (in 1ml dmso)
  • Variants: 4
from 587.68
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Carfilzomib, 98.00%
Chemat
  • size: 10mg, 25mg, 5mg
  • Variants: 3
from 380.46
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Carfilzomib, 98%
Thermo Scientific (Acros)
  • size: 100MG
  • Variants: 1
from 752.80
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Carfilzomib 98%
Ambeed
  • size: 5mg, 10mg, 50mg, 100mg
  • Variants: 6
from 298.06
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(αS)-α-[[2-(4-Morpholinyl)acetyl]amino]benzenebutanoyl-L-leucyl-N-[(1S)-3-methyl-1-[[(2R)-2-methyl-2-oxiranyl]carbonyl]butyl]-L-phenylalaninamide, 98%, 98%
Chemat
  • size: 1mg, 5mg, 10mg, 100mg
  • Variants: 6
from 122.00
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Carfilzomib, 99.98%
MedChemExpress
  • size: 1 g, 100 mg, 200 mg, 500 mg
  • Variants: 8
from 407.93
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Carfilzomib (Standard), 99.98%
MedChemExpress
  • size: 10 mg, 50 mg, 5 mg, 100 mg
  • Variants: 5
from 839.82
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Structural formula: {0} (CAS {1})

Carfilzomib is a synthetic tetrapeptide consisting of morpholin-4-acetyl, L-2-amino-4-phenylbutanoyl, L-leucyl and L-phenylalanyl residues joined in sequence with the C-terminus connected to the amino group of (2S)-2-amino-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-1-one via an amide linkage. Used for the treatment of patients with multiple myeloma. It has a role as an antineoplastic agent and a proteasome inhibitor. It is an epoxide, a member of morpholines and a tetrapeptide.

Source: ChEBI

Identity
Molecular formulaC40H57N5O7
Molecular weight719.9 g/mol
IUPAC name(2S)-4-methyl-N-[(2S)-1-[[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]-4-phenylbutanoyl]amino]pentanamide
InChIKeyBLMPQMFVWMYDKT-NZTKNTHTSA-N
SMILESCC(C)C[C@@H](C(=O)[C@]1(CO1)C)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC3=CC=CC=C3)NC(=O)CN4CCOCC4

Computed by PubChem (NCBI)

Synonyms: Carfilzomib, Kyprolis, carfilzomibum, Carfilzomib (PR-171), Carfilzomib (PR171), Carfilzomib [USAN], Carfilzomib [USAN:INN], CarfilzoMib salt, Kyprolis (TN), Carfilzomib; PR171
Related forms of this compound
(2R)-4-methyl-N-[(2S)-1-[[(2R)-4-methyl-1-[(2S)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-2-[[(2R)-2-[(2-morpholin-4-ylacetyl)amino]-4-phenylbutanoyl]amino]pentanamide C40H57N5O7
(2R)-4-methyl-N-[(2S)-1-[[4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-2-[[(2R)-2-[(2-morpholin-4-ylacetyl)amino]-4-phenylbutanoyl]amino]pentanamide C40H57N5O7
(2R)-4-methyl-N-[(2S)-1-[[4-methyl-1-[(2S)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-2-[[(2R)-2-[(2-morpholin-4-ylacetyl)amino]-4-phenylbutanoyl]amino]pentanamide C40H57N5O7
(2S)-4-methyl-N-[(2R)-1-[[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]-4-phenylbutanoyl]amino]pentanamide C40H57N5O7
(2S)-4-methyl-N-[(2S)-1-[[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-2-[[(2R)-2-[(2-morpholin-4-ylacetyl)amino]-4-phenylbutanoyl]amino]pentanamide C40H57N5O7
(2R)-4-methyl-N-[(2S)-1-[[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-2-[[(2S)-2-[(2-morpholin-4-ylacetyl)amino]-4-phenylbutanoyl]amino]pentanamide C40H57N5O7
(2S)-4-methyl-N-[(2S)-1-[[(2S)-4-methyl-1-[(2R)-2-methyloxiran-2-yl]-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-2-[[(2S)-2-[[2-(2,2,3,3,5,5,6,6-octadeuteriomorpholin-4-yl)acetyl]amino]-4-phenylbutanoyl]amino]pentanamide C40H57N5O7