cas: 670220-88-9 — see every product listed under this CAS number, including other names
Crenolanib 98% (CAS 670220-88-9) is a chemical reagent available from Chemat. Available pack sizes: 1mg, 5mg, 10mg, 25mg, 50mg, 100mg, 250mg, 1g. Offered by: Ambeed.
| brand | Ambeed |
|---|---|
| catalog number | A243601-1mg |
| cas | 670220-88-9 |
| size | 1mg |
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| brand | size | price | |
|---|---|---|---|
| Ambeed | 1mg | 225.75 Pln | |
| Ambeed | 5mg | 459.38 Pln | |
| Ambeed | 10mg | 681.88 Pln | |
| Ambeed | 25mg | 1160.25 Pln | |
| Ambeed | 50mg | 1377.19 Pln | |
| Ambeed | 100mg | 2228.25 Pln | |
| Ambeed | 250mg | 4664.62 Pln | |
| Ambeed | 1g | 14771.69 Pln |
| purity | 98% |
|---|---|
| delivery time | 1-2 weeks |
| ambeed catalog no. | A243601 |
Crenolanib is a member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a 8-(4-aminopiperidin-1-yl)quinolin-2-yl group at position 1 and by a (3-methyloxetan-3-yl)methoxy group at position 5. It is an inhibitor of type III tyrosine kinases, PDGFRalpha/beta and FLT3 (IC50 of 11, 3.2, and 4 nM). Currently under clinical development for the treatment of acute myeloid leukemia. It has a role as an antineoplastic agent, an angiogenesis inhibitor, an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor and an apoptosis inducer. It is a member of benzimidazoles, a member of quinolines, an aromatic ether, a member of oxetanes, an aminopiperidine and a tertiary amino compound.
Source: ChEBI
| Molecular formula | C26H29N5O2 |
|---|---|
| Molecular weight | 443.5 g/mol |
| IUPAC name | 1-[2-[5-[(3-methyloxetan-3-yl)methoxy]benzimidazol-1-yl]quinolin-8-yl]piperidin-4-amine |
| InChIKey | DYNHJHQFHQTFTP-UHFFFAOYSA-N |
| SMILES | CC1(COC1)COC2=CC3=C(C=C2)N(C=N3)C4=NC5=C(C=CC=C5N6CCC(CC6)N)C=C4 |
Computed by PubChem (NCBI)