Products 1642300-52-4

CAS 1642300-52-4 appears in our catalog under these names: Eltanexor/ 99.76% (existing batch purity), Eltanexor (KPT–8602) , Eltanexor(KPT-8602), Eltanexor 98%, (E)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-2-(pyrimidin-5-yl)acrylamide, 98%, 98%. Offered by: TargetMol, GLPBio, Biosynth, Ambeed, Chemat. Available pack sizes: 1mg, 2mg, 5mg, 10mg, 25mg, 50mg, 100mg, 500mg.

Eltanexor/ 99.76% (existing batch purity)
TargetMol
  • size: 1mg, 2mg, 5mg, 10mg
  • Variants: 8
from 578.44
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Eltanexor (KPT–8602) 
GLPBio
  • size: 1mg, 10mg, 100mg, 5mg
  • Variants: 6
from 629.80
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Eltanexor(KPT-8602)
Biosynth
  • size: 10mg, 25mg, 50mg
  • Variants: 3
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Eltanexor 98%
Ambeed
  • size: 1g, 1mg, 5mg, 10mg
  • Variants: 8
from 186.81
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(E)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-2-(pyrimidin-5-yl)acrylamide, 98%, 98%
Chemat
  • size: 1mg, 5mg, 10mg, 25mg
  • Variants: 7
from 165.20
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Eltanexor, 99.84%
MedChemExpress
  • size: 50 mg, 5 mg, 10 mg, 100 mg
  • Variants: 8
from 477.59
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(E)-3-(3-(3,5-Bis(trifluoromethyl)phenyl)-1H-1,2,4-triazol-1-yl)-2-(pyrimidin-5-yl)acrylamide, 98%
Fluorochem
  • size: 5mg, 10mg, 25mg, 50mg
  • Variants: 6
from 299.91
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Structural formula: {0} (CAS {1})

Eltanexor is a member of the class of triazoles that is 1H-1,2,4-triazole substituted by (1E)-3-amino-3-oxo-2-(pyrimidin-5-yl)prop-1-en-1-yl and 3,5-bis(trifluoromethyl)phenyl groups at positions 1 and 3, respectively. It is a second-generation exportin 1 inhibitor that is currently in phase II clinical trial for the treatment of patients with higher relapsed/refractory myelodysplastic neoplasms. It has a role as an exportin 1 inhibitor, an antineoplastic agent and an apoptosis inducer. It is a primary carboxamide, a member of triazoles, a member of pyrimidines, an enamide and a member of (trifluoromethyl)benzenes.

Source: ChEBI

Identity
Molecular formulaC17H10F6N6O
Molecular weight428.29 g/mol
IUPAC name(E)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-2-pyrimidin-5-ylprop-2-enamide
InChIKeyJFBAVWVBLRIWHM-AWNIVKPZSA-N
SMILESC1=C(C=C(C=C1C(F)(F)F)C(F)(F)F)C2=NN(C=N2)/C=C(\C3=CN=CN=C3)/C(=O)N

Computed by PubChem (NCBI)

Synonyms: Eltanexor, eltanexorum, Exportin 1 Inhibitor KPT-8602, Selective Inhibitor of Nuclear Export KPT-8602, Eltanexor [INN], Eltanexor [USAN], Eltanexor [WHO-DD], Eltanexor (KPT-8602), Eltanexor (USAN/INN), Eltanexor(KPT-8602)
Related forms of this compound
(Z)-3-[3-[3,5-bis(trifluoromethyl)phenyl]-1,2,4-triazol-1-yl]-2-pyrimidin-5-ylprop-2-enamide C17H10F6N6O