Products 167256-08-8
CAS 167256-08-8 appears in our catalog under these names: Enrasentan/ 97.96% (existing batch purity), Enrasentan, Enrasentan, 98.39%. Offered by: TargetMol, Chemat, MedChemExpress. Available pack sizes: 1mg, 5mg, 10mg, 25mg, 5 mg, 25 mg, 10 mg, 1 mg.
Enrasentan is a member of the class of indanes that is 2,3-dihydro-1H-indene which is substituted by a 1,3-benzodioxol-5-yl group, carboxy group, 2-(2-hydroxyethoxy)-4-methoxyphenyl group and a propoxy group at positions 1S, 2R, 3S and 5, respectively. It is an orally active mixed endothelin A/B receptor antagonist with a 100-fold greater affinity for the endothelin A receptor. The drug was being developed by GSK for the treatment of congestive heart failure and pulmonary hypertension (clinical trials discontinued). It has a role as an antihypertensive agent and an endothelin receptor antagonist. It is a primary alcohol, a monomethoxybenzene, a monocarboxylic acid, an aromatic ether, a member of benzodioxoles and a member of indanes.
Source: ChEBI
| Molecular formula | C29H30O8 |
|---|---|
| Molecular weight | 506.5 g/mol |
| IUPAC name | (1S,2R,3S)-1-(1,3-benzodioxol-5-yl)-3-[2-(2-hydroxyethoxy)-4-methoxyphenyl]-5-propoxy-2,3-dihydro-1H-indene-2-carboxylic acid |
| InChIKey | GLCKXJLCYIJMRB-UPRLRBBYSA-N |
| SMILES | CCCOC1=CC2=C(C=C1)[C@@H]([C@H]([C@@H]2C3=C(C=C(C=C3)OC)OCCO)C(=O)O)C4=CC5=C(C=C4)OCO5 |
Computed by PubChem (NCBI)