GDC–0623
cas: 1168091-68-6 — see every product listed under this CAS number, including other names
GDC–0623 (CAS 1168091-68-6) is a chemical reagent available from Chemat. Available pack sizes: 100mg, 1g, 25mg, 5mg, 10mM (in 1ml dmso), 500mg. Offered by: GLPBio.
| brand | GLPBio |
|---|---|
| catalog number | GC14247-100 |
| cas | 1168091-68-6 |
| size | 100mg |
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Available pack sizes
| brand | size | price | |
|---|---|---|---|
| GLPBio | 100mg | 2750.07 Pln | |
| GLPBio | 1g | 11624.30 Pln | |
| GLPBio | 25mg | 1579.94 Pln | |
| GLPBio | 5mg | 835.75 Pln | |
| GLPBio | 10mM (in 1ml dmso) | 1004.24 Pln | |
| GLPBio | 500mg | 7421.21 Pln |
properties
| purity | No data |
|---|---|
| delivery time | To be confirmed by Chemat |
GDC-0623 is a member of the class of imidazopyridines that is imidazo[1,5-a]pyridine substituted by (2-fluoro-4-iodophenyl)amino and (2-hydroxyethoxy)aminoacyl groups at positions 5 and 6. It is a potent ATP non-competitive inhibitor of MEK1 (Ki = 0.13nM) and also has efficacy against both mutant BRAF and mutant KRAS. It is in clinical development for treatment of patients with locally advanced or metastatic solid tumors. It has a role as an antineoplastic agent, an apoptosis inducer and an EC 2.7.12.2 (mitogen-activated protein kinase kinase) inhibitor. It is a primary alcohol, an organoiodine compound, an imidazopyridine, a substituted aniline, a secondary amino compound, a hydroxamic acid ester and a member of monofluorobenzenes.
Source: ChEBI
| Molecular formula | C16H14FIN4O3 |
|---|---|
| Molecular weight | 456.21 g/mol |
| IUPAC name | 5-(2-fluoro-4-iodoanilino)-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide |
| InChIKey | RFWVETIZUQEJEF-UHFFFAOYSA-N |
| SMILES | C1=CC(=C(C=C1I)F)NC2=C(C=CC3=CN=CN32)C(=O)NOCCO |
Computed by PubChem (NCBI)