Itraconazole

cas: 84625-61-6 — see every product listed under this CAS number, including other names

Itraconazole (CAS 84625-61-6) is a chemical reagent available from Chemat. Available pack sizes: on request, 1000mg, 10mg, 100mg, 1g, 200mg, 10mM (in 1ml dmso), 0,03kg. Offered by: Chemat Brand, Mikromol, LoGiCal, Dr. Ehrenstorfer.

brandChemat Brand
catalog numberULI031
cas84625-61-6
sizeon request
availability Do potwierdzenia przez Chemat|To be confirmed by Chemat
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Available pack sizes

brand size price
Chemat Brand on request price on request
Mikromol 1000mg price on request
LoGiCal 10mg price on request
Dr. Ehrenstorfer 100mg price on request
GLPBio 100mg 578.32 Pln
GLPBio 1g 1303.80 Pln
GLPBio 200mg 704.69 Pln
GLPBio 10mM (in 1ml dmso) 629.80 Pln
Biosynth 0,03kg price on request
Biosynth 0,05kg price on request
Biosynth 0,1kg price on request
Biosynth 0,25kg price on request
Biosynth 0,5kg price on request
HPC Standards 1x100mg 620.02 Pln

properties

purityNo data
categoryChemicals
delivery timeTo be confirmed by Chemat
Structural formula: {0} (CAS {1})

Itraconazole is an N-arylpiperazine that is cis-ketoconazole in which the imidazol-1-yl group is replaced by a 1,2,4-triazol-1-yl group and in which the actyl group attached to the piperazine moiety is replaced by a p-[(+-)1-sec-butyl-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl]phenyl group. A potent P-glycoprotein and CYP3A4 inhibitor, it is used as an antifungal drug for the treatment of various fungal infections, including aspergillosis, blastomycosis, candidiasis, chromoblastomycosis, coccidioidomycosis, cryptococcosis, histoplasmosis, and sporotrichosis. It has a role as a Hedgehog signaling pathway inhibitor, a P450 inhibitor and an EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor. It is a dichlorobenzene, an aromatic ether, a member of triazoles, a dioxolane, a N-arylpiperazine, a cyclic ketal, a conazole antifungal drug and a triazole antifungal drug.

Source: ChEBI

Identity
Molecular formulaC35H38Cl2N8O4
Molecular weight705.6 g/mol
IUPAC name2-butan-2-yl-4-[4-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one
InChIKeyVHVPQPYKVGDNFY-ZPGVKDDISA-N
SMILESCCC(C)N1C(=O)N(C=N1)C2=CC=C(C=C2)N3CCN(CC3)C4=CC=C(C=C4)OC[C@H]5CO[C@](O5)(CN6C=NC=N6)C7=C(C=C(C=C7)Cl)Cl

Computed by PubChem (NCBI)

Synonyms: itraconazole, Oriconazole, Sporanox, Itraconazol, Canditral, Traconal, Triasporin, Sporonox, Fungitraxx, Itraconazolo
Related forms of this compound
4-[4-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-(3,3,4,4,4-pentadeuteriobutan-2-yl)-1,2,4-triazol-3-one C35H38Cl2N8O4
2-butan-2-yl-4-[4-[4-[4-[[(2R,4R)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one C35H38Cl2N8O4
4-[4-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-(1,1,1-trideuteriobutan-2-yl)-1,2,4-triazol-3-one C35H38Cl2N8O4
2-butan-2-yl-4-[4-[4-[4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one C35H38Cl2N8O4
2-butan-2-yl-4-[4-[4-[4-[[(2S,4S)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one C35H38Cl2N8O4
2-butan-2-yl-4-[4-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one C35H38Cl2N8O4
Isomers (same molecular formula)
2-butan-2-yl-4-[4-[4-[4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-4-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one C35H38Cl2N8O4
2-butyl-4-[4-[4-[4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one C35H38Cl2N8O4

Also listed as

Itraconazole, 98% Combi-blocks CAS 84625-61-6
Itraconazole, >95% (HPLC) TRC CAS 84625-61-6
Itraconazole 2.0 mg/ml in Dimethyl Sulfoxide LoGiCal CAS 84625-61-6
Itraconazole/ 99.68% (existing batch purity) TargetMol CAS 84625-61-6
Itraconazole - Bio-X â„¢ Biosynth CAS 84625-61-6
Itraconazole, 99% Thermo Scientific (Acros) CAS 84625-61-6
Itraconazole, >98.0%(HPLC)(T) TCI CAS 84625-61-6
Itraconazole, 99.00% Chemat CAS 84625-61-6
Hh Signaling Antagonist X, I 1PC X 250MG Sigma-Aldrich CAS 84625-61-6
rel-4-[4-[4-[4-[[(2R,4S)-2-(2,4-Dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-2,4-dihydro-2-(1-methylpropyl)-3H-1,2,4-triazol-3-one, 98%, 98% Chemat CAS 84625-61-6
Itraconazole, BioScience Grade, 10 mg Roth CAS 84625-61-6
Itraconazole, min. 95 %, 50 g Roth CAS 84625-61-6
Itraconazole, min. 95 %, 100 g Roth CAS 84625-61-6
Itraconazole, 99.59% MedChemExpress CAS 84625-61-6
Itraconazole (Standard) MedChemExpress CAS 84625-61-6