L-685458, 99.48%
cas: 292632-98-5 — see every product listed under this CAS number, including other names
L-685458, 99.48% (CAS 292632-98-5) is a chemical reagent available from Chemat. Available pack sizes: 10 mg, 1 mg, 50 mg, 10mM/1mL, 25 mg, 5 mg. Offered by: MedChemExpress.
| brand | MedChemExpress |
|---|---|
| catalog number | HY-19369-10 mg |
| cas | 292632-98-5 |
| size | 10 mg |
| availability | In stock |
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Available pack sizes
| brand | size | price | |
|---|---|---|---|
| MedChemExpress | 10 mg | 3477.61 Pln | |
| MedChemExpress | 1 mg | 839.82 Pln | |
| MedChemExpress | 50 mg | 9236.17 Pln | |
| MedChemExpress | 10mM/1mL | 3315.07 Pln | |
| MedChemExpress | 25 mg | 6356.89 Pln | |
| MedChemExpress | 5 mg | 2279.46 Pln |
properties
| delivery time | 1-2 weeks |
|---|---|
| purity | 99.48% |
L-685,458 is a peptide and carboxamide that is L-leucyl-L-phenylalaninamide, L-Leu-L-Phe-NH2, which has been acylated on the N-terminus by a Phe-Phe hydroxyethylene dipeptide isotere, 2R-benzyl-5S-tert-butoxycarbonylamino-4R-hydroxy-6-phenylhexanoic acid. Compounds based on the structure of L-685,458 are potent inhibitors of gamma-secretase, which mediates the final catalytic step that generates the amyloid beta-peptide (Abeta), which assembles into the neurotoxic aggregates in the brains of sufferers of Alzheimer's disease. It has a role as a peptidomimetic and an EC 3.4.23.46 (memapsin 2) inhibitor. It is a peptide, a carbamate ester, a monocarboxylic acid amide and a secondary alcohol. It contains a tert-butoxycarbonyl group.
Source: ChEBI
| Molecular formula | C39H52N4O6 |
|---|---|
| Molecular weight | 672.9 g/mol |
| IUPAC name | tert-butyl N-[(2S,3R,5R)-6-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-benzyl-3-hydroxy-6-oxo-1-phenylhexan-2-yl]carbamate |
| InChIKey | MURCDOXDAHPNRQ-ZJKZPDEISA-N |
| SMILES | CC(C)C[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N)NC(=O)[C@H](CC2=CC=CC=C2)C[C@H]([C@H](CC3=CC=CC=C3)NC(=O)OC(C)(C)C)O |
Computed by PubChem (NCBI)