Products 292632-98-5

CAS 292632-98-5 appears in our catalog under these names: L–685,458, N-((2R,4R,5S)-5-(((1,1-Dimethylethoxy)carbonyl)amino)-4-hydroxy-1-oxo-6-phenyl-2-(phenylmethyl)hexyl)-L-leucyl-L-phenylalaninamide, L-685458/ 99.62% (existing batch purity), L-685458, L-685,458. Offered by: GLPBio, TRC, TargetMol, Biosynth, Ambeed. Available pack sizes: 5mg, 10mg, 1mg, 25mg, 50mg, 100mg, 0,05mg, 0,025mg.

L–685,458
GLPBio
  • size: 5mg, 1mg
  • Variants: 2
from 901.27
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N-((2R,4R,5S)-5-(((1,1-Dimethylethoxy)carbonyl)amino)-4-hydroxy-1-oxo-6-phenyl-2-(phenylmethyl)hexyl)-L-leucyl-L-phenylalaninamide
TRC
  • size: 10mg, 1mg, 5mg
  • Variants: 3
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L-685458/ 99.62% (existing batch purity)
TargetMol
  • size: 1mg, 5mg, 10mg, 25mg
  • Variants: 6
from 963.59
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L-685458
Biosynth
  • size: 0,05mg, 0,025mg, 0,1mg, 0,25mg
  • Variants: 5
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L-685,458
Biosynth
  • size: 1mg
  • Variants: 1
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L-685458 99%
Ambeed
  • size: 1mg, 5mg, 10mg
  • Variants: 3
from 648.50
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L-685458, 99%, 99%
Chemat
  • size: 1mg, 5mg, 10mg, 25mg
  • Variants: 4
from 592.40
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L-685458, 99.48%
MedChemExpress
  • size: 10 mg, 1 mg, 50 mg, 10mM/1mL
  • Variants: 6
from 839.82
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L-Phenylalaninamide, N-[(2R,4R,5S)-5-[[(1,1-dimethylethoxy)carbonyl]amino]-4-hydroxy-1-oxo-6-phenyl-2-(phenylmethyl)hexyl]-L-leucyl-, 99%
Fluorochem
  • size: 1mg, 5mg, 10mg
  • Variants: 3
from 1106.92
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Structural formula: {0} (CAS {1})

L-685,458 is a peptide and carboxamide that is L-leucyl-L-phenylalaninamide, L-Leu-L-Phe-NH2, which has been acylated on the N-terminus by a Phe-Phe hydroxyethylene dipeptide isotere, 2R-benzyl-5S-tert-butoxycarbonylamino-4R-hydroxy-6-phenylhexanoic acid. Compounds based on the structure of L-685,458 are potent inhibitors of gamma-secretase, which mediates the final catalytic step that generates the amyloid beta-peptide (Abeta), which assembles into the neurotoxic aggregates in the brains of sufferers of Alzheimer's disease. It has a role as a peptidomimetic and an EC 3.4.23.46 (memapsin 2) inhibitor. It is a peptide, a carbamate ester, a monocarboxylic acid amide and a secondary alcohol. It contains a tert-butoxycarbonyl group.

Source: ChEBI

Identity
Molecular formulaC39H52N4O6
Molecular weight672.9 g/mol
IUPAC nametert-butyl N-[(2S,3R,5R)-6-[[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-benzyl-3-hydroxy-6-oxo-1-phenylhexan-2-yl]carbamate
InChIKeyMURCDOXDAHPNRQ-ZJKZPDEISA-N
SMILESCC(C)C[C@@H](C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N)NC(=O)[C@H](CC2=CC=CC=C2)C[C@H]([C@H](CC3=CC=CC=C3)NC(=O)OC(C)(C)C)O

Computed by PubChem (NCBI)

Synonyms: l-685,458, GSI-X cpd, MURCDOXDAHPNRQ-ZJKZPDEISA-N, FTO, gamma-Secretase inhibitor X, orb1222403, orb1300391, L-685,458, >96% (HPLC), solid