LGK 974
cas: 1243244-14-5 — see every product listed under this CAS number, including other names
LGK 974 (CAS 1243244-14-5) is a chemical reagent available from Chemat. Available pack sizes: 10mg, 50mg. Offered by: Biosynth.
| brand | Biosynth |
|---|---|
| catalog number | FL76327-10mg |
| cas | 1243244-14-5 |
| size | 10mg |
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Available pack sizes
| brand | size | price | |
|---|---|---|---|
| Biosynth | 10mg | price on request | |
| Biosynth | 50mg | price on request |
properties
| category | Life Sciences |
|---|---|
| sub-category 1 | Ligands |
| sub-category 2 | Enzyme Modulators |
| purity | No data |
| delivery time | 1-2 weeks |
LGK974 is a carboxamide, the structure of which is that of acetamide substituted on carbon by a 2',3-dimethyl-2,4'-bipyridin-5-yl group and on nitrogen by a 5-(pyrazin-2-yl)pyridin-2-yl group. It is a highly potent, selective and orally bioavailable Porcupine inhibitor (a Wnt signalling inhibitor). It has a role as a Wnt signalling inhibitor. It is a secondary carboxamide, a member of pyridines, a member of pyrazines and a member of bipyridines. It is functionally related to an acetamide.
Source: ChEBI
| Molecular formula | C23H20N6O |
|---|---|
| Molecular weight | 396.4 g/mol |
| IUPAC name | 2-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-N-(5-pyrazin-2-yl-2-pyridinyl)acetamide |
| InChIKey | XXYGTCZJJLTAGH-UHFFFAOYSA-N |
| SMILES | CC1=CC(=CN=C1C2=CC(=NC=C2)C)CC(=O)NC3=NC=C(C=C3)C4=NC=CN=C4 |
Computed by PubChem (NCBI)
Synonyms:
[2,4'-Bipyridine]-5-acetamide, 2',3-dimethyl-N-[5-(2-pyrazinyl)-2-pyridinyl]-, PORCN inhibitor LGK974, Porcupine Inhibitor WNT974, 2-(2,3-Dimethyl-(2,4-bipyridin)-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide, 2-(2',3-Dimethyl-2,4'-bipyridin-5-yl)-N-[5-(2-pyrazinyl)-2-pyridi nyl]acetamide, Acotiamide Impurity LGK, orb1226688, orb1305261, s7143