LGK–974
cas: 1243244-14-5 — see every product listed under this CAS number, including other names
LGK–974 (CAS 1243244-14-5) is a chemical reagent available from Chemat. Available pack sizes: 5mg, 1g, 200mg, 10mM (in 1ml dmso), 50mg, 500mg. Offered by: GLPBio.
| brand | GLPBio |
|---|---|
| catalog number | GC12392-5 |
| cas | 1243244-14-5 |
| size | 5mg |
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Available pack sizes
| brand | size | price | |
|---|---|---|---|
| GLPBio | 5mg | 784.26 Pln | |
| GLPBio | 1g | 9574.24 Pln | |
| GLPBio | 200mg | 3924.88 Pln | |
| GLPBio | 10mM (in 1ml dmso) | 891.91 Pln | |
| GLPBio | 50mg | 2609.65 Pln | |
| GLPBio | 500mg | 6199.60 Pln |
properties
| purity | No data |
|---|---|
| delivery time | To be confirmed by Chemat |
LGK974 is a carboxamide, the structure of which is that of acetamide substituted on carbon by a 2',3-dimethyl-2,4'-bipyridin-5-yl group and on nitrogen by a 5-(pyrazin-2-yl)pyridin-2-yl group. It is a highly potent, selective and orally bioavailable Porcupine inhibitor (a Wnt signalling inhibitor). It has a role as a Wnt signalling inhibitor. It is a secondary carboxamide, a member of pyridines, a member of pyrazines and a member of bipyridines. It is functionally related to an acetamide.
Source: ChEBI
| Molecular formula | C23H20N6O |
|---|---|
| Molecular weight | 396.4 g/mol |
| IUPAC name | 2-[5-methyl-6-(2-methyl-4-pyridinyl)-3-pyridinyl]-N-(5-pyrazin-2-yl-2-pyridinyl)acetamide |
| InChIKey | XXYGTCZJJLTAGH-UHFFFAOYSA-N |
| SMILES | CC1=CC(=CN=C1C2=CC(=NC=C2)C)CC(=O)NC3=NC=C(C=C3)C4=NC=CN=C4 |
Computed by PubChem (NCBI)
Synonyms:
[2,4'-Bipyridine]-5-acetamide, 2',3-dimethyl-N-[5-(2-pyrazinyl)-2-pyridinyl]-, PORCN inhibitor LGK974, Porcupine Inhibitor WNT974, 2-(2,3-Dimethyl-(2,4-bipyridin)-5-yl)-N-(5-(pyrazin-2-yl)pyridin-2-yl)acetamide, 2-(2',3-Dimethyl-2,4'-bipyridin-5-yl)-N-[5-(2-pyrazinyl)-2-pyridi nyl]acetamide, Acotiamide Impurity LGK, orb1226688, orb1305261, s7143