LY3009120

LY3009120 is a member of the class of pyridopyrimidines that is pyrido[2,3-d]pyrimidine substituted by methylamino, 5-{[(3,3-dimethylbutyl)carbamoyl]amino}-4-fluoro-2-methylphenyl, and methyl groups at positions 2, 6 and 7, respectively. It is a potent pan RAF inhibitor which inhibits BRAFV600E, BRAFWT and CRAFWT (IC50 = 5.8, 9.1 and 15 nM, respectively). It also inhibits RAF homo- and heterodimers and exhibits anti-cancer properties. It has a role as an autophagy inducer, a necroptosis inhibitor, an antineoplastic agent, an apoptosis inducer and a B-Raf inhibitor. It is a member of phenylureas, an aminotoluene, an aromatic amine, a pyridopyrimidine, a secondary amino compound, a biaryl and a member of monofluorobenzenes.

Source: ChEBI

Computed by PubChem (NCBI)