cas: 1184173-73-6 — see every product listed under this CAS number, including other names
MK-8353 99% (CAS 1184173-73-6) is a chemical reagent available from Chemat. Available pack sizes: 10mg, 25mg, 50mg, 100mg, 250mg, 1g. Offered by: Ambeed.
| brand | Ambeed |
|---|---|
| catalog number | A480964-10mg |
| cas | 1184173-73-6 |
| size | 10mg |
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| brand | size | price | |
|---|---|---|---|
| Ambeed | 10mg | 759.75 Pln | |
| Ambeed | 25mg | 1382.75 Pln | |
| Ambeed | 50mg | 2300.56 Pln | |
| Ambeed | 100mg | 3863.62 Pln | |
| Ambeed | 250mg | 7273.44 Pln | |
| Ambeed | 1g | 23115.44 Pln |
| purity | 99% |
|---|---|
| delivery time | 2-3 weeks |
| ambeed catalog no. | A480964 |
MK-8353 is a member of the class of indazoles that is 1H-indazole substituted by a 6-(propan-2-yloxy)pyridin-3-yl group at position 3 and by a {[(3S)-3-(methylsulfanyl)-1-(2-{4-[4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl]-3,6-dihydropyridin-1(2H)-yl}-2-oxoethyl)pyrrolidin-3-yl]carbonyl}amino group at position 5. It is a potent and selective inhibitor of ERK1 and ERK2 in vitro (IC50 values of 23.0 nM and 8.8 nM, respectively). The drug is being developed by Merck Sharp & Dohme and is currently in clinical development for the treatment of advanced/metastatic solid tumors. It has a role as an antineoplastic agent, an apoptosis inducer and an EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor. It is a secondary carboxamide, a tertiary carboxamide, a member of pyridines, an aromatic ether, a member of triazoles, a member of indazoles, a pyrrolidinecarboxamide, a N-alkylpyrrolidine, a dihydropyridine and a methyl sulfide.
Source: ChEBI
| Molecular formula | C37H41N9O3S |
|---|---|
| Molecular weight | 691.8 g/mol |
| IUPAC name | (3S)-3-methylsulfanyl-1-[2-[4-[4-(1-methyl-1,2,4-triazol-3-yl)phenyl]-3,6-dihydro-2H-pyridin-1-yl]-2-oxoethyl]-N-[3-(6-propan-2-yloxy-3-pyridinyl)-1H-indazol-5-yl]pyrrolidine-3-carboxamide |
| InChIKey | KPQQGHGDBBJGFA-QNGWXLTQSA-N |
| SMILES | CC(C)OC1=NC=C(C=C1)C2=NNC3=C2C=C(C=C3)NC(=O)[C@@]4(CCN(C4)CC(=O)N5CCC(=CC5)C6=CC=C(C=C6)C7=NN(C=N7)C)SC |
Computed by PubChem (NCBI)