Products 171179-06-9
CAS 171179-06-9 appears in our catalog under these names: PD158780/ 99.16% (existing batch purity), PD 158780, PD 158780, >97.0%(HPLC), PD 158780, N4-(3-Bromophenyl)-N6-methylpyrido[3,4-d]pyrimidine-4,6-diamine. Offered by: TargetMol, GLPBio, TCI, Biosynth, Chemat. Available pack sizes: 2mg, 5mg, 10mg, 25mg, 50mg, 100mg, 200mg, 10mM/1mL.
PD158780 is a pyridopyrimidine that is pyrido[3,4-d]pyrimidine-4,6-diamine in which the amino groups at positions 4 and 6 are substituted by a m-bromophenyl group and a methyl group, respectively. It is a potent, cell-permeable, reversible ATP-competitive inhibitor of EGFR tyrosine kinase activity [IC50 values of 0.008, 49 and 52 nM for EGFR, ErbB2 (HER2) and Erb4 (HER4)]. It does not inhibit FGF or PDGF-mediated tyrosine phosphorylation. Induces G1 cell cycle arrest in MCF10A cells and is antiproliferative in A431 human epidermal carcinoma cells. It has a role as an antineoplastic agent and an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor. It is a diamine, an aromatic amine, a member of bromobenzenes, a pyridopyrimidine and a secondary amino compound.
Source: ChEBI
| Molecular formula | C14H12BrN5 |
|---|---|
| Molecular weight | 330.18 g/mol |
| IUPAC name | 4-N-(3-bromophenyl)-6-N-methylpyrido[3,4-d]pyrimidine-4,6-diamine |
| InChIKey | KFHMLBXBRCITHF-UHFFFAOYSA-N |
| SMILES | CNC1=NC=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)Br |
Computed by PubChem (NCBI)
Synonyms:
pd 158780, N4-(3-bromophenyl)-N6-methylpyrido[3,4-d]pyrimidine-4,6-diamine, 4-N-(3-bromophenyl)-6-N-methylpyrido[3,4-d]pyrimidine-4,6-diamine, N4-(3-Bromophenyl)-N6-methyl-pyrido[3,4-d]pyrimidine-4,6-diamine, 4-(3-bromoanilino)-6-methylaminopyrido[3,4-d]pyrimidine, 4-[(3-bromophenyl)amino]-6-(methylamino)pyrido[3,4-d]pyrimidine, 4-(3-bromoanilino)-6-(methylamino)pyrido[3,4-d]pyrimidine, N(4)-(3-bromophenyl)-N(6)-methylpyrido[3,4-d]pyrimidine-4,6-diamine, C14H12BrN5, N4-(3-Bromophenyl)-N6-methylpyrido(3,4-d)pyrimidine-4,6-diamine